Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children.
Angela
Allen
;
Stephen
Obaro
;
Kalifa
Bojang
;
Agnes A
Awomoyi
;
Brian M
Greenwood
;
Hilton
Whittle
;
Giorgio
Sirugo
;
Melanie J
Newport
;
(2003)
Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children.
The Pediatric infectious disease journal, 22 (11).
pp. 1018-1019.
ISSN 0891-3668
DOI: 10.1097/01.inf.0000095431.15606.68
;
Agnes A
Awomoyi
;
Brian M
Greenwood
;
Hilton
Whittle
;
Giorgio
Sirugo
;
Melanie J
Newport
;
(2003)
Variation in Toll-like receptor 4 and susceptibility to group A meningococcal meningitis in Gambian children.
The Pediatric infectious disease journal, 22 (11).
pp. 1018-1019.
ISSN 0891-3668
DOI: 10.1097/01.inf.0000095431.15606.68
Meningitis is an important cause of childhood mortality in sub-Saharan Africa. A case-control study investigating the role of the Toll-like receptor 4 gene in host susceptibility to Group A Neisseria meningitidis meningitis was conducted in 524 Gambian children. There was no association between a functional Toll-like receptor 4 gene polymorphism and meningitis, suggesting that this variant is not a major determinant of disease in this population.
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