Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom.

Weir, Rosemary E; Black, Gillian F; Dockrell, Hazel M; Floyd, Sian; Fine, Paul EM; Chaguluka, Steven D; Stenson, Sally; King, Elizabeth; Nazareth, Bernadette; Warndorff, David K; +7 more... Ngwira, Bagrey; Crampin, Amelia C; Mwaungulu, Lorren; Sichali, Lifted; Jarman, Elizabeth; Donovan, Linda; Blackwell, Jenefer M; (2004) Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom. Infection and immunity, 72 (3). pp. 1807-1811. ISSN 0019-9567 DOI: https://doi.org/10.1128/IAI.72.3.1807-1811.2004

Abstract

To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre	Population Studies Group
PubMed ID	14977992
ISI	189270800071
Related URLs	OA Location