Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom.
; Floyd, Sian; Fine, Paul EM; Chaguluka, Steven D; Stenson, Sally; King, Elizabeth; Nazareth, Bernadette; Warndorff, David K; +7 more...Ngwira, Bagrey; Crampin, Amelia C; Mwaungulu, Lorren; Sichali, Lifted; Jarman, Elizabeth; Donovan, Linda; and Blackwell, Jenefer M
(2004)
Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom.
Infection and immunity, 72 (3).
pp. 1807-1811.
ISSN 0019-9567
DOI: 10.1128/IAI.72.3.1807-1811.2004
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial purified protein derivatives (PPDs). The rank order in stimulatory potency for different PPDs was the same for all three cytokines. Before vaccination Malawians made higher pro- and anti-inflammatory responses than did United Kingdom subjects. Fewer than 5% of United Kingdom subjects made IL-10 in response to any PPD, compared to 19 to 57% responders among Malawians. Priming for regulatory IL-10 may contribute to the smaller increase in gamma interferon responses in Malawians compared to United Kingdom subjects following BCG vaccination.
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