Human cystic echinococcosis: evaluation of post-treatment serologic follow-up by IgG subclass antibody detection.
Lawn, Stephen D;
Bligh, John;
Craig, Philip S;
Chiodini, Peter L;
(2004)
Human cystic echinococcosis: evaluation of post-treatment serologic follow-up by IgG subclass antibody detection.
The American journal of tropical medicine and hygiene, 70 (3).
pp. 329-335.
ISSN 0002-9637
DOI: https://doi.org/10.4269/ajtmh.2004.70.329
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Assessment of post-treatment disease activity among patients with cystic echinococcosis (CE) is insensitive using detection of CE-specific total IgG antibody. This study investigated whether serum concentrations of CE-specific IgG subclasses 1-4 correlate better with disease activity than total IgG. We studied a cohort of patients (n = 28) with symptomatic CE treated with anthelminthic drugs and surgery and who were followed up clinically and radiologically for a mean of 5.6 years (range = 3-12 years). Serial archived sera collected during follow-up were retrospectively analyzed by enzyme-linked immunosorbent assays using crude horse hydatid cyst fluid as antigen. Changes in concentrations of antibodies were correlated with clinical and radiologic outcome. At diagnosis, concentrations of CE-specific total IgG, IgG1, and IgG2 antibodies were significantly elevated in a greater proportion of patients compared with IgG3 and IgG4 antibodies. During post-treatment follow up, the IgG2 antibody response provided the best correlate of disease activity.
