CD8+ T-cell priming regulated by cytokines of the innate immune system.
Stäger, Simona;
Kaye, Paul M;
(2004)
CD8+ T-cell priming regulated by cytokines of the innate immune system.
Trends in molecular medicine, 10 (8).
pp. 366-371.
ISSN 1471-4914
DOI: https://doi.org/10.1016/j.molmed.2004.06.003
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Host protection against a variety of pathogens and tumours requires the efficient induction of CD8(+) T-cell responses. Yet, it has proven difficult to develop vaccines that effectively stimulate this type of cellular immunity. One well-defined obstacle is antigen accessibility to the MHC class I processing pathway. However, cytokines that are produced by cells of the innate immune system also have a key role in CD8(+) T-cell responses, by enhancing 'cross-presentation' and/or inducing CD8(+) T-cell priming and differentiation. Here, we discuss how innate cytokine responses regulate CD8(+) T-cell immunity, and argue that a greater understanding of these processes will be essential for effective tailoring of vaccine-induced cellular immune responses.
