9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium.
; Fletcher, O; Orr, N; Johnson, N; Hopper, JL; Apicella, C; Southey, MC; Mahmoodi, M; Schmidt, MK; +133 more...Broeks, A; Cornelissen, S; Braaf, LM; Muir, KR; Lophatananon, A; Chaiwerawattana, A; Wiangnon, S; Fasching, PA; Beckmann, MW; Ekici, AB; Schulz-Wendtland, R; Sawyer, EJ; Tomlinson, I; Kerin, M; Burwinkel, B; Marme, F; Schneeweiss, A; Sohn, C; Guénel, P; Truong, T; Laurent-Puig, P; Mulot, C; Bojesen, SE; Nielsen, SF; Flyger, H; Nordestgaard, BG; Milne, RL; Benítez, J; Arias-Pérez, J; Zamora, MP; Anton-Culver, H; Ziogas, A; Bernstein, L; Dur, CC; Brenner, H; Müller, H; Arndt, V; Langheinz, A; Meindl, A; Golatta, M; Bartram, CR; Schmutzler, RK; Brauch, H; Justenhoven, C; Brüning, T; GENICA Network; Chang-Claude, J; Wang-Gohrke, S; Eilber, U; Dörk, T; Schürmann, P; Bremer, M; Hillemanns, P; Nevanlinna, H; Muranen, TA; Aittomäki, K; Blomqvist, C; Bogdanova, N; Antonenkova, N; Rogov, Y; Bermisheva, M; Prokofyeva, D; Zinnatullina, G; Khusnutdinova, E; Lindblom, A; Margolin, S; Mannermaa, A; Kosma, V; Hartikainen, JM; Kataja, V; Chenevix-Trench, G; Beesley, J; Chen, X; kConFab Investigators; Australian Ovarian Cancer Study Group; Lambrechts, D; Smeets, A; Paridaens, R; Weltens, C; Flesch-Janys, D; Buck, K; Behrens, S; Peterlongo, P; Bernard, L; Manoukian, S; Radice, P; Couch, FJ; Vachon, C; Wang, X; Olson, J; Giles, G; Baglietto, L; McLean, CA; Severi, G; John, EM; Miron, A; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Grip, M; Andrulis, IL; Knight, JA; Mulligan, AM; Weerasooriya, N; Devilee, P; Tollenaar, RA; Martens, JW; Seynaeve, CM; Hooning, MJ; Hollestelle, A; Jager, A; Tilanus-Linthorst, MM; Hall, P; Czene, K; Liu, J; Li, J; Cox, A; Cross, SS; Brock, IW; Reed, MW; Pharoah, P; Blows, FM; Dunning, AM; Ghoussaini, M; Ashworth, A; Swerdlow, A; Jones, M; Schoemaker, M; Easton, DF; Humphreys, M; Wang, Q; Peto, J; dos-Santos-Silva, I and
(2012)
9q31.2-rs865686 as a susceptibility locus for estrogen receptor-positive breast cancer: evidence from the Breast Cancer Association Consortium.
Cancer epidemiology, biomarkers & prevention, 21 (10).
pp. 1783-1791.
ISSN 1055-9965
DOI: 10.1158/1055-9965.EPI-12-0526
BACKGROUND: Our recent genome-wide association study identified a novel breast cancer susceptibility locus at 9q31.2 (rs865686). METHODS: To further investigate the rs865686-breast cancer association, we conducted a replication study within the Breast Cancer Association Consortium, which comprises 37 case-control studies (48,394 cases, 50,836 controls). RESULTS: This replication study provides additional strong evidence of an inverse association between rs865686 and breast cancer risk [study-adjusted per G-allele OR, 0.90; 95% confidence interval (CI), 0.88; 0.91, P = 2.01 × 10(-29)] among women of European ancestry. There were ethnic differences in the estimated minor (G)-allele frequency among controls [0.09, 0.30, and 0.38 among, respectively, Asians, Eastern Europeans, and other Europeans; P for heterogeneity (P(het)) = 1.3 × 10(-143)], but no evidence of ethnic differences in per allele OR (P(het) = 0.43). rs865686 was associated with estrogen receptor-positive (ER(+)) disease (per G-allele OR, 0.89; 95% CI, 0.86-0.91; P = 3.13 × 10(-22)) but less strongly, if at all, with ER-negative (ER(-)) disease (OR, 0.98; 95% CI, 0.94-1.02; P = 0.26; P(het) = 1.16 × 10(-6)), with no evidence of independent heterogeneity by progesterone receptor or HER2 status. The strength of the breast cancer association decreased with increasing age at diagnosis, with case-only analysis showing a trend in the number of copies of the G allele with increasing age at diagnosis (P for linear trend = 0.0095), but only among women with ER(+) tumors. CONCLUSIONS: This study is the first to show that rs865686 is a susceptibility marker for ER(+) breast cancer. IMPACT: The findings further support the view that genetic susceptibility varies according to tumor subtype.
-
picture_as_pdf - 9q31.2-rs865686 as a Susceptibility Locus_GREEN AAM.pdf
-
subject - Accepted Version
-
- Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 3.0