Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.
Richard K
Amewu
;
James
Chadwick
;
Afthab
Hussain
;
Somnath
Panda
;
Rinki
Rinki
;
Omar
Janneh
;
Stephen A
Ward
;
Candel
Miguel
;
Hollie
Burrell-Saward
;
Livia
Vivas
;
+1 more...
Paul M
O'Neill
;
(2013)
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers.
Bioorganic & medicinal chemistry, 21 (23).
pp. 7392-7397.
ISSN 0968-0896
DOI: 10.1016/j.bmc.2013.09.047
The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC(50)s versus colon (HT29-AK and leukemia (HL60) cell lines.
| Item Type | Article |
|---|---|
| ISI | 326374600013 |
| Date Deposited | 03 Dec 2013 21:03 |