Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Lindström, S; Vachon, CM; Li, J; Varghese, J; Thompson, D; Warren, R; Brown, J; Leyland, J; Audley, T; Wareham, NJ; +25 more...Loos, RJ; Paterson, AD; Rommens, J; Waggott, D; Martin, LJ; Scott, CG; Pankratz, VS; Hankinson, SE; Hazra, A; Hunter, DJ; Hopper, JL; Southey, MC; Chanock, SJ; Silva, IdS; Liu, J; Eriksson, L; Couch, FJ; Stone, J; Apicella, C; Czene, K; Kraft, P; Hall, P; Easton, DF; Boyd, NF; Tamimi, RM and
(2011)
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Nature genetics, 43 (3).
pp. 185-187.
ISSN 1061-4036
DOI: 10.1038/ng.760
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
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