Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Sara
Lindström
;
Celine M
Vachon
;
Jingmei
Li
;
Jajini
Varghese
;
Deborah
Thompson
;
Ruth
Warren
;
Judith
Brown
;
Jean
Leyland
;
Tina
Audley
;
Nicholas J
Wareham
;
+25 more...
Ruth JF
Loos
;
Andrew D
Paterson
;
Johanna
Rommens
;
Darryl
Waggott
;
Lisa J
Martin
;
Christopher G
Scott
;
V Shane
Pankratz
;
Susan E
Hankinson
;
Aditi
Hazra
;
David J
Hunter
;
John L
Hopper
;
Melissa C
Southey
;
Stephen J
Chanock
;
Isabel dos Santos
Silva
;
JianJun
Liu
;
Louise
Eriksson
;
Fergus J
Couch
;
Jennifer
Stone
;
Carmel
Apicella
;
Kamila
Czene
;
Peter
Kraft
;
Per
Hall
;
Douglas F
Easton
;
Norman F
Boyd
;
Rulla M
Tamimi
;
(2011)
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Nature genetics, 43 (3).
pp. 185-187.
ISSN 1061-4036
DOI: 10.1038/ng.760
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
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