Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data.

J Sastre-Garriga ; GT Ingle ; M Rovaris ; N Téllez ; B Jasperse ; DR Altmann ; B Benedetti ; VL Stevenson ; M Cercignani ; SM Leary ; +10 more... F Barkhof ; B Brochet ; V Dousset ; M Filippi ; X Montalban ; NF Kalkers ; CH Polman ; A Rovira ; DH Miller ; AJ Thompson ; (2005) Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data. Neurology, 65 (4). pp. 633-635. ISSN 0028-3878 DOI: 10.1212/01.wnl.0000173061.12776.1f
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The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS.

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