Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data.

Sastre-Garriga, J; Ingle, G; Rovaris, M; Téllez, N; Jasperse, B; Altmann, D; Benedetti, B; Stevenson, V; Cercignani, M; Leary, S; +10 more...Barkhof, F; Brochet, B; Dousset, V; Filippi, M; Montalban, X; Kalkers, N; Polman, C; Rovira, A; Miller, D; Thompson, A and (2005) Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data. Neurology, 65 (4). pp. 633-635. ISSN 0028-3878 DOI: 10.1212/01.wnl.0000173061.12776.1f
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The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS.

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