Plasmid copy number and disease severity in naturally occurring ocular Chlamydia trachomatis infection.
Last, Anna R
; Roberts, Chrissy H; Cassama, Eunice; Nabicassa, Meno; Molina-Gonzalez, Sandra; Burr, Sarah E; Mabey, David CW; Bailey, Robin L; and Holland, Martin J
(2013)
Plasmid copy number and disease severity in naturally occurring ocular Chlamydia trachomatis infection.
Journal of clinical microbiology, 52 (1).
pp. 324-327.
ISSN 0095-1137
DOI: 10.1128/JCM.02618-13
; Roberts, Chrissy H; Cassama, Eunice; Nabicassa, Meno; Molina-Gonzalez, Sandra; Burr, Sarah E; Mabey, David CW; Bailey, Robin L; and Holland, Martin J
(2013)
Plasmid copy number and disease severity in naturally occurring ocular Chlamydia trachomatis infection.
Journal of clinical microbiology, 52 (1).
pp. 324-327.
ISSN 0095-1137
DOI: 10.1128/JCM.02618-13
The Chlamydia trachomatis plasmid is a virulence factor. Plasmid copy number, C. trachomatis load and disease severity were assessed in a treatment-naive population where trachoma is hyperendemic. By using droplet digital PCR, plasmid copy number was found to be stable (median, 5.34 [range, 1 to 18]) and there were no associations with C. trachomatis load or disease severity.
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subject - Published Version
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