AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection.
Lawn, SD;
(2004)
AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection.
The Journal of infection, 48 (1).
pp. 1-12.
ISSN 0163-4453
DOI: https://doi.org/10.1016/j.jinf.2003.09.001
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The intimate relationship between the HIV-1 life-cycle and the activation state of cells supporting viral replication results in a dynamic interaction between coinfections and HIV-1 replication in dually infected people. The immunologic impact of recurrent coinfections has the potential to increase viral replication, viral genotypic heterogeneity and CD4 T lymphocyte loss, leading to accelerated decline in immune function, reduced survival and increased HIV-1 transmission risk. These effects may play a particularly significant role in the HIV-1 epidemic in sub-Saharan Africa. The mechanisms underlying these effects on virus-host dynamics are reviewed and data describing the impact of tuberculosis, malaria, schistosomiasis and genital ulceration on HIV-1 infection are presented.
