Comparison of careHPV and hybrid capture 2 assays for detection of high-risk human Papillomavirus DNA in cervical samples from HIV-1-infected African women.
Ngou, Jean;
Magooa, Mahlape P;
Gilham, Clare;
Djigma, Florencia;
Didelot, Marie-Noelle;
Kelly, Helen;
Yonli, Albert;
Sawadogo, Bernard;
Lewis, David A;
Delany-Moretlwe, Sinead;
+3 more...Mayaud, Philippe;
Segondy, Michel;
HARP Study Group;
(2013)
Comparison of careHPV and hybrid capture 2 assays for detection of high-risk human Papillomavirus DNA in cervical samples from HIV-1-infected African women.
Journal of clinical microbiology, 51 (12).
pp. 4240-4242.
ISSN 0095-1137
DOI: https://doi.org/10.1128/JCM.02144-13
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The careHPV and HC2 assays were compared for high-risk human papillomavirus (HR-HPV) DNA detection in cervical samples from 149 HIV-1-infected African women. The HR-HPV DNA detection rates were 37.6% and 34.9% for careHPV and HC2, respectively. Agreement between the two tests was 94.6% (95% confidence interval [CI], 89.7% to 97.7%) with a kappa value of 0.88 (95% CI, 0.81 to 0.96), indicating an excellent agreement. careHPV may be considered as suitable as HC2 for cervical cancer screening among HIV-infected African women.