Lawlor, DA; Ebrahim, S; Smith, G Davey; (2004) Smoking before the birth of a first child is not associated with increased risk of breast cancer: findings from the British Women's Heart and Health Cohort Study and a meta-analysis. British journal of cancer, 91 (3). pp. 512-518. ISSN 0007-0920 DOI: https://doi.org/10.1038/sj.bjc.6601916
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Abstract
It has been suggested that the period between puberty and first birth is a time when the breast is particularly susceptible to carcinogenic effects. In a cohort of 3047 women aged 60-79 years (N=139 breast cancer cases), we found no association between smoking before the birth of a first child and breast cancer risk: fully adjusted (for age, number of children, age at birth of first child, age at menarche, age at menopausal, hysterectomy and/or oophorectomy, ever use of oral contraception, use of hormone replacement therapy, alcohol consumption, body mass index, childhood and adulthood social class) odds ratio 1.06 (95% confidence interval: 0.72, 1.56). The pooled estimate from a meta-analysis of our study and 11 previously published studies (N=6528 cases) was 1.07 (0.94, 1.22). We conclude that smoking prior to the birth of a first child is not associated with increased risk of breast cancer.
Item Type | Article |
---|---|
Keywords | Aged, Breast Neoplasms/*etiology, Cohort Studies, Female, Humans, Middle Aged, *Parity, *Pregnancy, Risk Factors, Smoking/*adverse effects, Aged, Breast Neoplasms, etiology, Cohort Studies, Female, Humans, Middle Aged, Parity, Pregnancy, Risk Factors, Smoking, adverse effects |
Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
Research Centre | Centre for Global Non-Communicable Diseases (NCDs) |
PubMed ID | 15226777 |
ISI | 222930400017 |
Related URLs |
Download
Filename: Smoking before the birth of a first child is not associated with increased risk of breast cancer_GOLD VoR.pdf
Licence: Creative Commons: Attribution-Noncommercial-Share Alike 3.0
Download