Lawlor, Debbie A; Ebrahim, Shah; Davey Smith, George; British women's heart and health study; (2002) Socioeconomic position in childhood and adulthood and insulin resistance: cross sectional survey using data from British women's heart and health study. BMJ, 325 (7368). 805-. ISSN 1468-5833 DOI: https://doi.org/10.1136/bmj.325.7368.805
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Abstract
OBJECTIVE: To assess the associations between childhood and adulthood social class and insulin resistance. DESIGN: Cross sectional survey. SETTING: 23 towns across England, Scotland, and Wales. PARTICIPANTS: 4286 women aged 60-79 years. MAIN OUTCOME MEASURES: Insulin resistance and other cardiovascular disease risk factors. RESULTS: Belonging to manual social classes in childhood and in adulthood was independently associated with increased insulin resistance, dyslipidaemia, and general obesity. The association between childhood social class and insulin resistance was stronger than that for adult social class. The effect, on insulin resistance and other risk factors, of belonging to a manual social class at either stage in the life course was cumulative, with no evidence of an interaction between childhood and adult social class. Women who were in manual social classes in childhood remained at increased risk of insulin resistance, dyslipidaemia, and obesity--even if they moved into non-manual social classes in adulthood--compared with women who were in non-manual social classes at both stages. CONCLUSIONS: Adverse social circumstances in childhood, as well as adulthood, are strongly and independently associated with increased risk of insulin resistance and other metabolic risk factors.
Item Type | Article |
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Keywords | Aged, Cardiovascular Diseases/epidemiology, Child, Cross-Sectional Studies, Female, Great Britain/epidemiology, Humans, *Insulin Resistance, Metabolic Diseases/epidemiology, Middle Aged, Research Support, Non-U.S. Gov't, Risk Factors, *Social Class, Social Mobility, Aged, Cardiovascular Diseases, epidemiology, Child, Cross-Sectional Studies, Female, Great Britain, epidemiology, Humans, Insulin Resistance, Metabolic Diseases, epidemiology, Middle Aged, Research Support, Non-U.S. Gov't, Risk Factors, Social Class, Social Mobility |
Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
Research Centre | Centre for Global Non-Communicable Diseases (NCDs) |
PubMed ID | 12376440 |
ISI | 178648700017 |
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