Boulanger, Denis; Sarr, Jean Biram; Fillol, Florie; Sokhna, Cheikh; Cisse, Badara; Schacht, Anne-Marie; Trape, Jean-François; Riveau, Gilles; Simondon, François; Greenwood, Brian; +1 more... Remoué, Franck; (2010) Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children. Malaria journal, 9 (1). 363-. ISSN 1475-2875 DOI: https://doi.org/10.1186/1475-2875-9-363
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Abstract
BACKGROUND: Intermittent preventive treatment in children (IPTc) is a promising strategy to control malaria morbidity. A significant concern is whether IPTc increases children's susceptibility to subsequent malaria infection by altering their anti-Plasmodium acquired immunity. METHODS: To investigate this concern, IgG antibody (Ab) responses to Plasmodium falciparum schizont extract were measured in Senegalese children (6 months-5 years old) who had received three rounds of IPTc with artesunate + sulphadoxine-pyrimethamine (or placebo) at monthly intervals eight months earlier. Potential confounding factors, such as asexual malaria parasitaemia and nutritional status were also evaluated. RESULTS: Firstly, a bivariate analysis showed that children who had received IPTc had lower anti-Plasmodium IgG Ab levels than the non-treated controls. When epidemiological parameters were incorporated into a multivariate regression, gender, nutritional status and haemoglobin concentration did not have any significant influence. In contrast, parasitaemia, past malaria morbidity and increasing age were strongly associated with a higher specific IgG response. CONCLUSIONS: The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses. Previous IPTc does not seem to interfere with this parasite-dependent acquired humoral response eight months after the last drug administration.
Item Type | Article |
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Faculty and Department |
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
Research Centre |
Centre for Maternal, Reproductive and Child Health (MARCH) Malaria Centre |
PubMed ID | 21167018 |
ISI | 287604500001 |
Related URLs |