Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Cross-Disorder Group of the Psychiatric Genomics Consortium ; S Hong Lee ; Stephan Ripke ; Benjamin M Neale ; Stephen V Faraone ; Shaun M Purcell ; Roy H Perlis ; Bryan J Mowry ; Anita Thapar ; Michael E Goddard ; +362 more... 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Susan L Santangelo ; Joseph A Sergeant ; Russell Schachar ; Martin Schalling ; Alan F Schatzberg ; William A Scheftner ; Gerard D Schellenberg ; Stephen W Scherer ; Nicholas J Schork ; Thomas G Schulze ; Johannes Schumacher ; Markus Schwarz ; Edward Scolnick ; Laura J Scott ; Jianxin Shi ; Paul D Shilling ; Stanley I Shyn ; Jeremy M Silverman ; Susan L Slager ; Susan L Smalley ; Johannes H Smit ; Erin N Smith ; Edmund JS Sonuga-Barke ; David St Clair ; Matthew State ; Michael Steffens ; Hans-Christoph Steinhausen ; John S Strauss ; Jana Strohmaier ; T Scott Stroup ; James S Sutcliffe ; Peter Szatmari ; Szabocls Szelinger ; Srinivasa Thirumalai ; Robert C Thompson ; Alexandre A Todorov ; Federica Tozzi ; Jens Treutlein ; Manfred Uhr ; Edwin JCG van den Oord ; Gerard Van Grootheest ; Jim Van Os ; Astrid M Vicente ; Veronica J Vieland ; John B Vincent ; Peter M Visscher ; Christopher A Walsh ; Thomas H Wassink ; Stanley J Watson ; Myrna M Weissman ; Thomas Werge ; Thomas F Wienker ; Ellen M Wijsman ; Gonneke Willemsen ; Nigel Williams ; A Jeremy Willsey ; Stephanie H Witt ; Wei Xu ; Allan H Young ; Timothy W Yu ; Stanley Zammit ; Peter P Zandi ; Peng Zhang ; Frans G Zitman ; Sebastian Zöllner ; Bernie Devlin ; John R Kelsoe ; Pamela Sklar ; Mark J Daly ; Michael C O'Donovan ; Nicholas Craddock ; Patrick F Sullivan ; Jordan W Smoller ; Kenneth S Kendler ; Naomi R Wray ; International Inflammatory Bowel Disease Genetics Consortium (II ; (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature genetics, 45 (9). pp. 984-994. ISSN 1061-4036 DOI: 10.1038/ng.2711
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Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 ± 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 ± 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 ± 0.06 s.e.), and ADHD and major depressive disorder (0.32 ± 0.07 s.e.), low between schizophrenia and ASD (0.16 ± 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Item Type Article
Keywords attention-deficit/hyperactivity disorder, deficit hyperactivity, disorder, autism spectrum disorders, major depressive disorder, bipolar, disorder, common snps, crohns-disease, schizophrenia, risk, association
ISI 323748200007
Date Deposited 23 Sep 2013 19:24

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