Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.
Polley, Rosalind;
Stager, Simona;
Prickett, Sara;
Maroof, Asher;
Zubairi, Soombul;
Smith, Deborah F;
Kaye, Paul M;
(2006)
Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen.
Infection and immunity, 74 (1).
pp. 773-776.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.74.1.773-776.2006
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CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.