A road map for efficient and reliable human genome epidemiology.

John PA Ioannidis ; Marta Gwinn ; Julian Little ; Julian PT Higgins ; Jonine L Bernstein ; Paolo Boffetta ; Melissa Bondy ; Molly S Bray ; Paul E Brenchley ; Patricia A Buffler ; +29 more... Juan Pablo Casas ; Anand Chokkalingam ; John Danesh ; George Davey Smith ; Siobhan Dolan ; Ross Duncan ; Nelleke A Gruis ; Patricia Hartge ; Mia Hashibe ; David J Hunter ; Marjo-Riitta Jarvelin ; Beatrice Malmer ; Demetrius M Maraganore ; Julia A Newton-Bishop ; Thomas R O'Brien ; Gloria Petersen ; Elio Riboli ; Georgia Salanti ; Daniela Seminara ; Liam Smeeth ORCID logo ; Emanuela Taioli ; Nic Timpson ; Andre G Uitterlinden ; Paolo Vineis ; Nick Wareham ; Deborah M Winn ; Ron Zimmern ; Muin J Khoury ; Human Genome Epidemiology Network and the Network of Investigato ; (2006) A road map for efficient and reliable human genome epidemiology. Nature genetics, 38 (1). pp. 3-5. ISSN 1061-4036 DOI: 10.1038/ng0106-3
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Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews.

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