Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.
Yindom, Louis-Marie;
Leligdowicz, Aleksandra;
Martin, Maureen P;
Gao, Xiaojiang;
Qi, Ying;
Zaman, Syed MA;
van der Loeff, Maarten Schim;
van Tienen, Carla;
Jaye, Assan;
Aveika, Akum;
+7 more...Worwui, Archibald;
Diatta, Mathurin;
Vincent, Tim;
Whittle, Hilton C;
Rowland-Jones, Sarah L;
Walton, Robert;
Carrington, Mary;
(2010)
Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.
Journal of virology, 84 (16).
pp. 8202-8208.
ISSN 0022-538X
DOI: https://doi.org/10.1128/JVI.00116-10
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Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after HIV-2 infection and that HLA-B*0801 is associated with susceptibility to infection. Interestingly, previous data indicate that HLA-B*1503 is associated with low viral loads in HIV-1 clade B infection but has no significant effect on viral load in clade C infection. In general, alleles strongly associated with HIV-1 disease showed no effect in HIV-2 disease. These data emphasize the unique nature of the effects of HLA and HLA/KIR combinations on HIV-2 immune responses relative to HIV-1, which could be related to their distinct clinical course.