Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
Frodsham, Angela J;
Zhang, Lyna;
Dumpis, Uga;
Taib, Nor Azizah Mohd;
Best, Steve;
Durham, Andrew;
Hennig, Branwen JW;
Hellier, Simon;
Knapp, Susanne;
Wright, Mark;
+7 more...Chiaramonte, Maria;
Bell, John I;
Graves, Mary;
Whittle, Hilton C;
Thomas, Howard C;
Thursz, Mark R;
Hill, Adrian VS;
(2006)
Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
Proceedings of the National Academy of Sciences of the United States of America, 103 (24).
pp. 9148-9153.
ISSN 0027-8424
DOI: https://doi.org/10.1073/pnas.0602800103
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in approximately 350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type I IFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-lambdas, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling.
