Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.
Hilary A
Archer
;
Paul
Edison
;
David J
Brooks
;
Jo
Barnes
;
Chris
Frost
;
Tom
Yeatman
;
Nick C
Fox
;
Martin N
Rossor
;
(2006)
Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.
Annals of neurology, 60 (1).
pp. 145-147.
ISSN 0364-5134
DOI: 10.1002/ana.20889
To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. (11)C-PIB((11)C-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional (11)C-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.
Item Type | Article |
---|---|
Keywords | Brain atrophy, serial mri, volume, validation, dementia |
ISI | 238825500021 |
Date Deposited | 17 Oct 2011 18:52 |
ORCID: https://orcid.org/0000-0003-0098-9915