Teran, Rommy; Mitre, Edward; Vaca, Maritza; Erazo, Silvia; Oviedo, Gisela; Hübner, Marc P; Chico, Martha E; Mattapallil, Joseph J; Bickle, Quentin; Rodrigues, Laura C; +1 more... Cooper, Philip J; (2011) Immune system development during early childhood in tropical Latin America: evidence for the age-dependent down regulation of the innate immune response. Clinical immunology (Orlando, Fla), 138 (3). pp. 299-310. ISSN 1521-6616 DOI: https://doi.org/10.1016/j.clim.2010.12.011
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Abstract
The immune response that develops in early childhood underlies the development of inflammatory diseases such as asthma and there are few data from tropical Latin America (LA). This study investigated the effects of age on the development of immunity during the first 5 years of life by comparing innate and adaptive immune responses in Ecuadorian children aged 6-9 months, 22-26 months, and 48-60 months. Percentages of naïve CD4+ T cells declined with age while those of memory CD4(+) and CD8(+) T cells increased indicating active development of the immune system throughout the first five years. Young infants had greater innate immune responses to TLR agonists compared to older children while regulatory responses including SEB-induced IL-10 and percentages of FoxP3(+) T-regulatory cells decreased with age. Enhanced innate immunity in early life may be important for host defense against pathogens but may increase the risk of immunopathology.
Item Type | Article |
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Keywords | Innate immunity, Adaptive immunity, Childhood, Tropics, T-CELLS, CYTOKINE RESPONSES, HYGIENE HYPOTHESIS, ASTHMA, DIFFERENTIATION, MODULATION, MATURATION, INFECTION, DISEASE, HEALTH |
Faculty and Department |
Faculty of Infectious and Tropical Diseases > Department of Infection Biology > Dept of Immunology and Infection (-2019) Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) |
Research Centre | Centre for Maternal, Reproductive and Child Health (MARCH) |
PubMed ID | 21247809 |
ISI | 287683300008 |
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