Ssemwanga, Deogratius; Lyagoba, Frederick; Ndembi, Nicaise; Mayanja, Billy N; Larke, Natasha; Wang, Shuyi; Baalwa, Joshua; Williamson, Carolyn; Grosskurth, Heiner; Kaleebu, Pontiano; (2011) Multiple HIV-1 infections with evidence of recombination in heterosexual partnerships in a low risk Rural Clinical Cohort in Uganda. Virology, 411 (1). pp. 113-131. ISSN 0042-6822 DOI: https://doi.org/10.1016/j.virol.2010.12.025
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Abstract
We report on the frequency of multiple infections, generation of recombinants and consequences on disease progression in 35 HIV-1 infected individuals from 7 monogamous and 6 polygamous partnerships within a Rural Clinical Cohort in Uganda. The env-C2V3, gag-p24 and pol-IN genes were sequenced. Single genome amplified half genome sequences were used to map recombination breakpoints. Three participants were dually infected with subtypes A and D, one case with subtype A and A/D recombinant and the fifth with 2 phylogenetically distinct A/D recombinants. Occurrence of A/D recombination was observed in two multiple infected individuals. Rate of late stage WHO events using Cox regression was 3 times greater amongst multiple infected compared to singly infected individuals (hazard ratio 3.35; 95% CI 1.09, 10.3; p=0.049). We have shown that polygamous relationships involving subtype discordant partnerships was a major contributor of multiple infections with generation of inter subtype recombinants in our cohort.
Item Type | Article |
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Keywords | HIV-1, Multiple infections, Superinfection, Coinfection, Recombination, IMMUNODEFICIENCY-VIRUS TYPE-1, INJECTION-DRUG USERS, DISEASE, PROGRESSION, DUAL INFECTION, SUBTYPE-B, MOLECULAR EPIDEMIOLOGY, LONG-TERM, IN-DEPTH, SUPERINFECTION, PATIENT |
Faculty and Department |
Faculty of Epidemiology and Population Health > Dept of Medical Statistics Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) MRC Uganda > UG-HIV Care |
Research Centre | Tropical Epidemiology Group |
PubMed ID | 21239033 |
ISI | 287630200012 |
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