Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.
Amewu, Richard;
Stachulski, Andrew V;
Ward, Stephen A;
Berry, Neil G;
Bray, Patrick G;
Davies, Jill;
Labat, Gael;
Vivas, Livia;
O'Neill, Paul M;
(2006)
Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin.
Organic & biomolecular chemistry, 4 (24).
pp. 4431-4436.
ISSN 1477-0520
DOI: https://doi.org/10.1039/b613565j
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Unsymmetrical dispiro- and spirotetraoxanes have been designed and synthesized via acid-catalyzed cyclocondensation of bis(hydroperoxides) with ketones. Incorporation of water-soluble and polar functionalities, via reductive amination and amide bond formation, produces several analogues with low nanomolar in vitro antimalarial activity. Several analogues display an unprecedented level of oral antimalarial activity for this class of endoperoxide drug.
