Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam.
Thiem, VD; Deen, JL; von Seidlein, L; Canh, DG; Anh, DD; Park, J; Ali, M; Danovaro-Holliday, MC; Son, ND; Hoa, NT; +2 more...Holmgren, J; Clemens, JD and
(2006)
Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam.
Vaccine, 24 (20).
pp. 4297-4303.
ISSN 0264-410X
DOI: 10.1016/j.vaccine.2006.03.008
We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera.
| Item Type | Article |
|---|---|
| Keywords | Administration, Oral, Adult, Case-Control Studies, Child, Cholera/epidemiology/*prevention & control, Cholera Vaccines/administration & dosage/*immunology, Confounding Factors (Epidemiology), Disease Outbreaks, Humans, Vietnam/epidemiology, Administration, Oral, Adult, Case-Control Studies, Child, Cholera, epidemiology, prevention & control, Cholera Vaccines, administration & dosage, immunology, Confounding Factors (Epidemiology), Disease Outbreaks, Humans, Vietnam, epidemiology |
| ISI | 238016600008 |
| Date Deposited | 17 Oct 2011 18:05 |