Strain-dependent variation in Mycobacterium bovis BCG-induced human T-cell activation and gamma interferon production in vitro.
Aguirre-Blanco, Ana M;
Lukey, Pauline T;
Cliff, Jacqueline M;
Dockrell, Hazel M;
(2007)
Strain-dependent variation in Mycobacterium bovis BCG-induced human T-cell activation and gamma interferon production in vitro.
Infection and immunity, 75 (6).
pp. 3197-3201.
ISSN 0019-9567
DOI: https://doi.org/10.1128/IAI.01611-06
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Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals. Glaxo 1077 exhibited the greatest stimulatory capacity, followed by Pasteur 1173 and then Danish 1331. These differences may affect in vitro stimulation and vaccination-induced immunogenicity.
