Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.
Cehovin, Ana;
Cliff, Jacqueline M;
Hill, Philip C;
Brookes, Roger H;
Dockrell, Hazel M;
(2007)
Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection.
Clinical and vaccine immunology, 14 (6).
pp. 796-798.
ISSN 1556-6811
DOI: https://doi.org/10.1128/CVI.00093-07
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To test the hypothesis that prolonged culture would enhance the sensitivity of latent tuberculosis detection by a gamma interferon release assay, blood samples from 33 household contacts of Gambian tuberculosis patients were stimulated with Mycobacterium tuberculosis-specific antigens. After 24 h of culture, 66% were positive, compared to 93% after 6 days of culture.
