Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon.
Torimiro, JN; Wolfe, ND; Thomas, A; Martin, MP; Mpoudi-Ngole, E; Tamoufe, U; Birx, DL; Carrington, M; Burke, DS; Carr, JK and
(2007)
Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon.
AIDS (London, England), 21 (4).
pp. 527-528.
ISSN 0269-9370
DOI: 10.1097/QAD.0b013e328045c4bd
Among rural populations in Cameroon, HIV-1 prevalence is low and the genetic diversity broad. An unusual population-level genetic background may modulate this pattern of HIV infection. We examined HIV-1 prevalence, CCR5Delta32 and CCR5 promoter -2459 G genotype frequency among 1390 rural inhabitants. No individual was identified with the CCR5Delta32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported.
| Item Type | Article |
|---|---|
| ISI | 244910000019 |
| Date Deposited | 17 Oct 2011 17:55 |