Mendelsohn, Joshua B; Calzavara, Liviana; Bullock, Sandra; Iveniuk, James; Tan, Darrell HS; Burchell, Ann N; Bourne, Adam; Lebouché, Bertrand; Daftary, Amrita; Moravan, Veronika; +3 more... Loutfy, Mona; Conway, Brian; Positive Plus One Study Team; (2022) Disclosure of HIV-serodiscordant relationships and association with viral suppression: results from the Positive Plus One study. AIDS care, 35 (7). pp. 1037-1044. ISSN 0954-0121 DOI: https://doi.org/10.1080/09540121.2021.2019669
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Abstract
BACKGROUND: Little is known about the effects of disclosure of HIV-serodiscordant relationships on clinical outcomes. We aimed to evaluate the effect of relationship disclosure on HIV viral suppression, and hypothesized that disclosure by HIV-positive and HIV-negative partners would be associated with viral suppression in the HIV-positive partner. METHODS: We conducted a Canadian national online and telephone-administered survey of HIV-positive and HIV-negative partners in serodiscordant relationships. The primary outcome was self-reported viral suppression. Multivariable analyses were undertaken using Firth logistic regression. RESULTS: We recruited 540 participants in current serodiscordant relationships (n = 228 HIV-negative; n = 312 HIV-positive). Similar proportions of HIV-positive and HIV-negative partners disclosed their relationship to healthcare professionals (82% v. 76%, p = 0.13). Among HIV-positive partners, disclosure of the relationship to healthcare professionals increased the odds of viral suppression (aOR = 4.7; CI: 2.13, 10.51) after adjusting for age, education, and relationship turmoil due to HIV. Increasing age (aOR = 1.28; 95% CI = 1.07, 1.55) and education (aOR = 2.43; 95% CI = 1.15, 5.26) were also associated with viral suppression. Among HIV-negative partners, relationship disclosure was not associated with viral suppression and HIV-negative heterosexual men were less likely to report that their HIV-positive partners were virally suppressed (aOR = 0.24; CI: 0.09, 0.61). CONCLUSIONS: Disclosure of HIV-serodiscordant status by HIV-positive participants to healthcare professionals was associated with increased odds of viral suppression. Similar effects were not evident among HIV-negative participants. Future work should explore factors that empower relationship disclosure and incorporate them into supportive services for HIV-serodiscordant relationships.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) |
PubMed ID | 35416092 |
Elements ID | 176595 |
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Filename: Disclosure of HIV serodiscordant relationships and association with viral suppression results from the Positive Plus One study.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
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