Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February.

Grint, Daniel J; Wing, Kevin; Williamson, Elizabeth; McDonald, Helen I; Bhaskaran, Krishnan; Evans, David; Evans, Stephen Jw; Walker, Alex J; Hickman, George; Nightingale, Emily; +26 more... Schultze, Anna; Rentsch, Christopher T; Bates, Chris; Cockburn, Jonathan; Curtis, Helen J; Morton, Caroline E; Bacon, Sebastian; Davy, Simon; Wong, Angel Ys; Mehrkar, Amir; Tomlinson, Laurie; Douglas, Ian J; Mathur, Rohini; Blomquist, Paula; MacKenna, Brian; Ingelsby, Peter; Croker, Richard; Parry, John; Hester, Frank; Harper, Sam; DeVito, Nicholas J; Hulme, Will; Tazare, John; Goldacre, Ben; Smeeth, Liam; Eggo, Rosalind M; (2021) Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February. Eurosurveillance, 26 (11). pp. 10-15. ISSN 1025-7917 DOI: https://doi.org/10.2807/1560-7917.ES.2021.26.11.2100256

Abstract

The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.34-2.09; p < 0.0001). Absolute risk of death by 28 days increased with age and comorbidities. This VOC has potential to spread faster with higher mortality than the pandemic to date.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology Faculty of Epidemiology and Population Health > Dept of Medical Statistics Academic Services & Administration > Directorate
Research Centre	Covid-19 Research EHR Research Group Centre for the Mathematical Modelling of Infectious Diseases ?? 181801 ??
PubMed ID	33739254
Elements ID	158158