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doi:10.1371/journal.pntd.0008937
Tomoko Hiraoka, Ngo Chi Cuong, Sugihiro Hamaguchi, Mihoko Kikuchi, Shungo Katoh, Le Kim Anh, Nguyen Thi Hien Anh, Dang Duc Anh, Chris Smith, Haruhiko Maruyama, Lay-Myint Yoshida, Do Duy Cuong, Pham Thanh Thuy, Koya Ariyoshi
Meningitis patients with Angiostrongylus cantonensis may present without eosinophilia in the cerebrospinal fluid in northern Vietnam
10.1371/journal.pntd.0008937
http://dx.doi.org/10.1371/journal.pntd.0008937
2020-12-22
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34.9795 742.734 216.567 12.3591 re
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Q
Q
Q
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BT
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(.)Tj
/F14 1 Tf
1.1056 0 Td
(\r)Tj
/F9 1 Tf
(.)Tj
0.0907 -1.2983 Td
(For)Tj
1.627 0 Td
(the)Tj
1.4684 0 Td
(real-time)Tj
3.8551 0 Td
(PCR)Tj
2.0636 0 Td
(for)Tj
/F14 1 Tf
1.3889 0 Td
()Tj
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.1226 0 Td
()Tj
/F9 1 Tf
(,)Tj
4.8132 0 Td
(we)Tj
1.3266 0 Td
(designed)Tj
3.7642 0 Td
(two)Tj
1.7065 0 Td
(sets)Tj
1.6668 0 Td
(of)Tj
1.0148 0 Td
(oligonucleotide)Tj
6.4062 0 Td
(primers)Tj
3.3505 0 Td
(to)Tj
-36.7707 -1.3039 Td
(amplify)Tj
3.2485 0 Td
(a)Tj
0.652 0 Td
(144-bp)Tj
3.0217 0 Td
(fragment)Tj
3.8664 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(first)Tj
1.8085 0 Td
(internal)Tj
3.3562 0 Td
(transcribed)Tj
4.7564 0 Td
(spacer)Tj
2.7496 0 Td
(\(ITS1\))Tj
2.8006 0 Td
(gene)Tj
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(of)Tj
/F14 1 Tf
1.0148 0 Td
()Tj
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.1225 0 Td
()Tj
/F9 1 Tf
-32.961 -1.2983 Td
(and)Tj
1.7292 0 Td
(a)Tj
0.6519 0 Td
(115-bp)Tj
3.0217 0 Td
(fragment)Tj
3.8722 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(second)Tj
3.0104 0 Td
(internal)Tj
3.3562 0 Td
(transcribed)Tj
4.7564 0 Td
(spacer)Tj
2.7496 0 Td
(\(ITS2\))Tj
2.8006 0 Td
(gene)Tj
2.0806 0 Td
(of)Tj
/F14 1 Tf
1.0148 0 Td
()Tj
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.1225 0 Td
()Tj
/F9 1 Tf
(,)Tj
-32.6492 -1.2982 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(Primer3)Tj
/F15 1 Tf
0 Tc
3.5093 0 Td
(<)Tj
0.83 0.64 0.02 0 k
/F9 1 Tf
-0.004 Tc
(https://primer3plus.com/cgi)Tj
12.0188 0 Td
(-bin/dev/primer3plus.cgi)Tj
/F15 1 Tf
0 Tc
(>)Tj
0 g
/F9 1 Tf
-0.004 Tc
11.0039 0 Td
(with)Tj
2.0013 0 Td
(GenBank)Tj
-32.2807 -1.304 Td
(accession)Tj
3.9685 0 Td
(no.)Tj
1.5024 0 Td
(AB181155.)Tj
4.5581 0 Td
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1.7858 0 Td
(primers)Tj
3.3505 0 Td
(targeting)Tj
3.7927 0 Td
(ITS1)Tj
2.1203 0 Td
(were)Tj
2.1259 0 Td
(Gspi-ITS1F)Tj
4.8586 0 Td
(\(5'-CATCGGCTCTG)Tj
-28.0628 -1.2982 Td
(ATCTTCGCT-3'\))Tj
7.4324 0 Td
(and)Tj
1.7292 0 Td
(Gspi-ITS1R)Tj
4.9606 0 Td
(\(5'-AGACACCAACGGATGCT)Tj
12.8861 0 Td
(GTT-3'\);)Tj
3.7644 0 Td
(the)Tj
1.4683 0 Td
(primers)Tj
3.3505 0 Td
(tar-)Tj
-35.5915 -1.2983 Td
(geting)Tj
2.6873 0 Td
(ITS2)Tj
2.1203 0 Td
(were)Tj
2.1259 0 Td
(Gspi-ITS2F)Tj
4.8586 0 Td
(\(5'-CATTCATCGAGC)Tj
9.3543 0 Td
(GGCAAGTG-3'\))Tj
7.1034 0 Td
(and)Tj
1.7292 0 Td
(Gspi-ITS2R)Tj
4.9549 0 Td
(\(5'-)Tj
-34.9339 -1.2983 Td
(GCGTACGCACCTCGATA)Tj
11.4123 0 Td
(AGA-3'\).)Tj
3.9061 0 Td
(After)Tj
2.2904 0 Td
(confirming)Tj
4.7223 0 Td
(that)Tj
1.7802 0 Td
(the)Tj
/F14 1 Tf
1.4683 0 Td
()Tj
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.1225 0 Td
()Tj
/F9 1 Tf
4.5865 0 Td
(positive)Tj
3.3165 0 Td
(control)Tj
-34.6051 -1.3039 Td
(showed)Tj
3.2485 0 Td
(a)Tj
0.6577 0 Td
(single)Tj
2.5285 0 Td
(band)Tj
2.2393 0 Td
(by)Tj
1.1792 0 Td
(conventional)Tj
5.4255 0 Td
(PCR)Tj
2.0636 0 Td
(with)Tj
2.0012 0 Td
(each)Tj
2.0296 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(two)Tj
1.7064 0 Td
(sets)Tj
1.6668 0 Td
(of)Tj
1.0148 0 Td
(primers,)Tj
3.5773 0 Td
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(GoTaq)Tj
-34.2082 -1.2982 Td
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2.1487 0 Td
(DNA)Tj
2.3754 0 Td
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4.8189 0 Td
(\(Promega)Tj
4.1442 0 Td
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5.4368 0 Td
(Madison,)Tj
3.9797 0 Td
(WI,)Tj
1.7518 0 Td
(USA\),)Tj
2.6816 0 Td
(we)Tj
1.3266 0 Td
(performed)Tj
4.473 0 Td
(SYBR)Tj
-33.1367 -1.2983 Td
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(Real-time)Tj
4.1046 0 Td
(PCR)Tj
2.0636 0 Td
(for)Tj
/F14 1 Tf
1.3889 0 Td
()Tj
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.1225 0 Td
()Tj
/F9 1 Tf
4.5865 0 Td
(using)Tj
2.3924 0 Td
(each)Tj
2.0239 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4739 0 Td
(two)Tj
1.7065 0 Td
(sets)Tj
1.6667 0 Td
(of)Tj
1.0148 0 Td
(primers)Tj
3.3506 0 Td
(with)Tj
1.9955 0 Td
(Power)Tj
-32.6038 -1.3039 Td
(SYBR)Tj
2.5285 0 Td
(Green)Tj
2.7043 0 Td
(PCR)Tj
2.0636 0 Td
(Master)Tj
2.999 0 Td
(Mix)Tj
1.8425 0 Td
(\(Thermo)Tj
3.8211 0 Td
(Fisher)Tj
2.6986 0 Td
(Scientific,)Tj
4.1271 0 Td
(Waltham,)Tj
4.1726 0 Td
(MA,)Tj
2.0239 0 Td
(USA\))Tj
2.4548 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(7500)Tj
-33.8171 -1.2983 Td
(Real)Tj
1.9446 0 Td
(Time)Tj
2.3414 0 Td
(PCR)Tj
2.0636 0 Td
(System)Tj
3.0501 0 Td
(\(Applied)Tj
3.7474 0 Td
(Biosystems,)Tj
4.8755 0 Td
(Foster)Tj
2.7099 0 Td
(City,)Tj
2.1316 0 Td
(CA,)Tj
1.7914 0 Td
(USA\).)Tj
2.6816 0 Td
(The)Tj
1.7801 0 Td
(positive)Tj
3.3166 0 Td
(control)Tj
3.1237 0 Td
(for)Tj
/F14 1 Tf
-35.5575 -1.2982 Td
()Tj
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.1226 0 Td
()Tj
/F9 1 Tf
4.5864 0 Td
(was)Tj
1.7008 0 Td
(its)Tj
1.1452 0 Td
(whole)Tj
2.6078 0 Td
(genome,)Tj
3.634 0 Td
(which)Tj
2.6475 0 Td
(was)Tj
1.7008 0 Td
(kindly)Tj
2.7609 0 Td
(provided)Tj
3.8154 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.474 0 Td
(Department)Tj
5.091 0 Td
(of)Tj
1.0148 0 Td
(Hel-)Tj
-34.4804 -1.304 Td
(minthology,)Tj
5.0854 0 Td
(Faculty)Tj
3.1351 0 Td
(of)Tj
1.0148 0 Td
(Tropical)Tj
3.5943 0 Td
(Medicine,)Tj
4.2179 0 Td
(Mahidol)Tj
3.6227 0 Td
(University.)Tj
4.6316 0 Td
(The)Tj
1.7802 0 Td
(whole-genome)Tj
6.1455 0 Td
(DNA)Tj
2.3754 0 Td
(con-)Tj
-35.6029 -1.2982 Td
(centration)Tj
4.337 0 Td
(was)Tj
1.7008 0 Td
(3100)Tj
2.1203 0 Td
(ng/mm)Tj
ET
Q
q
1 j
1 J
0.0001 w
7.4999 0 0 6.6659 311.471 386.872 cm
BT
/F9 1 Tf
-0.0053 Tc
1 TL
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 314.986 382.394 cm
BT
/F9 1 Tf
-0.004 Tc
1 TL
0 0 Td
(.)Tj
0.4478 0 Td
(The)Tj
1.7802 0 Td
(upper)Tj
2.5795 0 Td
(limit)Tj
2.1203 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(positive)Tj
3.3165 0 Td
(control)Tj
3.1181 0 Td
(dilution)Tj
3.4129 0 Td
(was)Tj
1.6951 0 Td
(1,000,000)Tj
-32.4507 -1.2982 Td
(times)Tj
2.3868 0 Td
(for)Tj
1.3889 0 Td
(detection)Tj
3.9345 0 Td
(by)Tj
1.1849 0 Td
(SYBR)Tj
2.5284 0 Td
(Green)Tj
2.7042 0 Td
(Real-time)Tj
4.1045 0 Td
(PCR.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 334.205 cm
BT
/F16 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Statistical)Tj
4.3228 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 317.197 cm
BT
/F9 1 Tf
-0.004 Tc
1 TL
0 0 Td
(We)Tj
1.61 0 Td
(showed)Tj
3.2485 0 Td
(the)Tj
1.4683 0 Td
(demographic)Tj
5.5049 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
3.0784 0 Td
(characteristics)Tj
5.9074 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0239 0 Td
(EM/PM)Tj
3.4639 0 Td
(group)Tj
2.6079 0 Td
(with)Tj
2.0012 0 Td
(those)Tj
2.3358 0 Td
(of)Tj
-35.9941 -1.2982 Td
(the)Tj
1.4683 0 Td
(other)Tj
2.3471 0 Td
(patients)Tj
3.3675 0 Td
(using)Tj
2.3924 0 Td
(frequencies)Tj
4.7849 0 Td
(and)Tj
1.7291 0 Td
(percentages)Tj
4.9096 0 Td
(for)Tj
1.3833 0 Td
(categorical)Tj
4.5184 0 Td
(values)Tj
2.6645 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(median)Tj
3.2428 0 Td
(and)Tj
-36.0054 -1.3039 Td
(interquartile)Tj
5.2043 0 Td
(range)Tj
2.4605 0 Td
(\(IQR\))Tj
2.6078 0 Td
(for)Tj
1.389 0 Td
(continuous)Tj
4.7338 0 Td
(variables.)Tj
3.9458 0 Td
(When)Tj
2.6873 0 Td
(we)Tj
1.3266 0 Td
(were)Tj
2.1203 0 Td
(comparing)Tj
4.5751 0 Td
(CSF)Tj
-31.0505 -1.2983 Td
(eosinophils)Tj
/F7 1 Tf
0 Tc
4.7508 0 Td
()Tj
/F9 1 Tf
-0.004 Tc
0.9921 0 Td
(10%)Tj
1.9276 0 Td
(group)Tj
2.6078 0 Td
(with)Tj
2.0013 0 Td
(other)Tj
2.347 0 Td
(definition)Tj
4.1613 0 Td
(group)Tj
2.6078 0 Td
(individually)Tj
4.989 0 Td
(or)Tj
1.0998 0 Td
(comparing)Tj
4.5751 0 Td
(the)Tj
1.4683 0 Td
(EM/PM)Tj
-33.5279 -1.2983 Td
(criteria)Tj
3.0727 0 Td
(not)Tj
1.576 0 Td
(fulfilled)Tj
3.2825 0 Td
(group)Tj
2.6079 0 Td
(with)Tj
1.9956 0 Td
(each)Tj
2.0296 0 Td
(definition)Tj
4.1612 0 Td
(group)Tj
2.6079 0 Td
(individually,)Tj
5.2157 0 Td
(categorical)Tj
4.5127 0 Td
(variables)Tj
3.719 0 Td
(were)Tj
-34.7808 -1.2982 Td
(compared)Tj
4.2406 0 Td
(by)Tj
1.1848 0 Td
(Fisher's)Tj
3.2712 0 Td
(exact)Tj
2.2677 0 Td
(test,)Tj
1.8255 0 Td
(and)Tj
1.7291 0 Td
(continuous)Tj
4.7395 0 Td
(variables)Tj
3.719 0 Td
(were)Tj
2.1203 0 Td
(compared)Tj
4.2463 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(Mann-Whit-)Tj
-31.9916 -1.3039 Td
(ney)Tj
1.644 0 Td
(nonparametric)Tj
6.1852 0 Td
(test.)Tj
1.8255 0 Td
(We)Tj
1.6101 0 Td
(calculated)Tj
4.2065 0 Td
(the)Tj
1.4684 0 Td
(odds)Tj
2.143 0 Td
(ratio)Tj
2.0976 0 Td
(\(OR\))Tj
2.2677 0 Td
(with)Tj
1.9956 0 Td
(95%)Tj
1.9332 0 Td
(confidence)Tj
4.5978 0 Td
(intervals)Tj
-31.9746 -1.2983 Td
(using)Tj
2.3867 0 Td
(logistic)Tj
3.0557 0 Td
(regression)Tj
4.32 0 Td
(analysis.)Tj
3.5546 0 Td
(In)Tj
1.1055 0 Td
(addition,)Tj
3.8211 0 Td
(we)Tj
1.3323 0 Td
(calculated)Tj
4.2009 0 Td
(p-values)Tj
3.5376 0 Td
(among)Tj
2.9934 0 Td
(the)Tj
1.4683 0 Td
(4)Tj
0.6973 0 Td
(groups)Tj
2.9707 0 Td
(by)Tj
-35.4441 -1.2983 Td
(Kruskal-Wallis)Tj
6.2021 0 Td
(test)Tj
1.5987 0 Td
(for)Tj
1.389 0 Td
(continues)Tj
4.1216 0 Td
(variables)Tj
3.719 0 Td
(and)Tj
1.7291 0 Td
(Chi-square)Tj
4.6545 0 Td
(test)Tj
1.5987 0 Td
(for)Tj
1.389 0 Td
(categorical)Tj
4.5127 0 Td
(variables.)Tj
3.9458 0 Td
(Statis-)Tj
-34.8602 -1.3039 Td
(tical)Tj
1.8878 0 Td
(analysis)Tj
3.3279 0 Td
(was)Tj
1.6951 0 Td
(conducted)Tj
4.4277 0 Td
(using)Tj
2.3924 0 Td
(STATA)Tj
3.2882 0 Td
(version)Tj
3.1521 0 Td
(15)Tj
1.1678 0 Td
(\(StataCorp)Tj
4.5638 0 Td
(LLC,)Tj
2.1826 0 Td
(College)Tj
3.1918 0 Td
(Station,)Tj
-31.2772 -1.2983 Td
(TX77845)Tj
3.8607 0 Td
(USA\).)Tj
2.6816 0 Td
(All)Tj
1.3946 0 Td
(tests)Tj
1.9616 0 Td
(were)Tj
2.1259 0 Td
(two-tailed,)Tj
4.4788 0 Td
(and)Tj
1.7347 0 Td
(p)Tj
/F15 1 Tf
0 Tc
0.737 0 Td
(<)Tj
/F9 1 Tf
-0.004 Tc
0.9922 0 Td
(0.05)Tj
1.8708 0 Td
(was)Tj
1.7008 0 Td
(considered)Tj
4.5978 0 Td
(statistically)Tj
4.6091 0 Td
(significant.)Tj
ET
Q
q
1 j
1 J
0.0001 w
11.9999 0 0 11.9999 200.012 151.994 cm
BT
/F3 1 Tf
-0.0033 Tc
1 TL
0 0 Td
(Results)Tj
ET
Q
q
1 j
1 J
0.0001 w
10 0 0 10 200.012 134.986 cm
BT
/F9 1 Tf
-0.004 Tc
1 TL
0 0 Td
(During)Tj
3.135 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
2.3924 0 Td
(period,)Tj
3.0557 0 Td
(from)Tj
2.2054 0 Td
(June)Tj
2.0523 0 Td
(2012)Tj
2.1203 0 Td
(to)Tj
1.0261 0 Td
(May)Tj
2.0012 0 Td
(2014,)Tj
2.3471 0 Td
(7,505)Tj
2.3471 0 Td
(patients)Tj
3.3732 0 Td
(were)Tj
2.1203 0 Td
(admitted)Tj
3.8154 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
-34.486 -1.2982 Td
(department,)Tj
5.1079 0 Td
(and)Tj
1.7292 0 Td
(2,458)Tj
2.347 0 Td
(patients)Tj
3.3676 0 Td
(were)Tj
2.126 0 Td
(hospitalized)Tj
5.0059 0 Td
(with)Tj
2.0013 0 Td
(undiagnosed)Tj
5.3574 0 Td
(febrile)Tj
2.7439 0 Td
(illness.)Tj
2.897 0 Td
(Among)Tj
-32.6832 -1.2983 Td
(them,)Tj
2.5114 0 Td
(679)Tj
1.6498 0 Td
(patients)Tj
3.3675 0 Td
(underwent)Tj
4.5751 0 Td
(lumbar)Tj
3.1238 0 Td
(puncture)Tj
3.8607 0 Td
(and)Tj
1.7292 0 Td
(were)Tj
2.1203 0 Td
(enrolled.)Tj
3.7417 0 Td
(Abnormal)Tj
4.3369 0 Td
(CSF)Tj
1.8879 0 Td
(was)Tj
1.6951 0 Td
(found)Tj
-34.5994 -1.3039 Td
(in)Tj
1.0318 0 Td
(431)Tj
1.6497 0 Td
(\(63.5%\))Tj
3.3109 0 Td
(patients.)Tj
3.5943 0 Td
(Blood)Tj
2.5851 0 Td
(samples)Tj
3.3846 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(patients)Tj
3.3675 0 Td
(\(100%\))Tj
3.0841 0 Td
(were)Tj
2.1203 0 Td
(available,)Tj
3.8948 0 Td
(and)Tj
1.7291 0 Td
(CSF)Tj
1.8879 0 Td
(samples)Tj
-33.8001 -1.2983 Td
(of)Tj
1.0147 0 Td
(473)Tj
1.6441 0 Td
(patients)Tj
3.3676 0 Td
(\(69.7%\))Tj
3.3108 0 Td
(were)Tj
2.126 0 Td
(available)Tj
3.6623 0 Td
(for)Tj
1.389 0 Td
(this)Tj
1.6724 0 Td
(study.)Tj
ET
Q
q
1 j
1 J
0.0001 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
Q
q
34.9795 742.734 216.567 12.3591 re
W* n
q
1 0 0 1 34.9795 742.734 cm
q
/I5 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0.0001 w
7.9999 0 0 7.9999 366.293 745.795 cm
BT
/F0 1 Tf
-0.005 Tc
1 TL
0 0 Td
(Parasit)Tj
3.0543 0 Td
(ic)Tj
0.9284 0 Td
(meningiti)Tj
3.9189 0 Td
(s)Tj
0.7157 0 Td
(without)Tj
3.3308 0 Td
(eosinophilia)Tj
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