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Ikanyeng D. Seipone, Ravesh Singh, Vinod B. Patel, Avashna Singh, Michelle L. Gordon, Daniel M. Muema, Keertan Dheda, Thumbi Ndung’u
Tuberculous meningitis is associated with higher cerebrospinal HIV-1 viral loads compared to other HIV-1-associated meningitides
www.plosone.org
www.plosone.org
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2.9877 0 Td
(state,)Tj
2.262 0 Td
(consent)Tj
3.3278 0 Td
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3.7304 0 Td
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2.211 0 Td
(a)Tj
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(first)Tj
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(degree)Tj
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(rela-)Tj
-34.9906 -1.3039 Td
(tive)Tj
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(the)Tj
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(of)Tj
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(lumbar)Tj
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(puncture)Tj
3.8551 0 Td
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(clinically)Tj
3.7757 0 Td
(justified)Tj
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0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
-33.8681 -1.2982 Td
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(three)Tj
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(different)Tj
3.6566 0 Td
(groups)Tj
2.9707 0 Td
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1.0148 0 Td
(follows;)Tj
3.2825 0 Td
(1\))Tj
1.0375 0 Td
(TBM)Tj
2.3017 0 Td
(\(either)Tj
2.8743 0 Td
(PCR)Tj
2.0636 0 Td
(or)Tj
1.0942 0 Td
(CSF)Tj
-35.0813 -1.2983 Td
(culture)Tj
3.0387 0 Td
(positive)Tj
3.3165 0 Td
(for)Tj
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1.3833 0 Td
[()]TJ
/F6 1 Tf
(.)Tj
/F10 1 Tf
[()16()]TJ
/F6 1 Tf
2.0919 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(16,)Tj
1.3946 0 Td
(with)Tj
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(15)Tj
1.1735 0 Td
(antiretroviral)Tj
5.5105 0 Td
(therapy)Tj
3.2485 0 Td
(\(ART\)-na)Tj
/F13 1 Tf
[()]TJ
/F6 1 Tf
(ve\),)Tj
5.8507 0 Td
(the)Tj
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1.4683 0 Td
[()]TJ
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(.)Tj
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[()16()]TJ
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2.092 0 Td
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1.7234 0 Td
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4.8812 0 Td
(GmbH,)Tj
3.2485 0 Td
(Roche)Tj
2.7156 0 Td
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3.3959 0 Td
(Science,)Tj
3.4299 0 Td
(Mannheim,)Tj
-32.91 -1.3039 Td
(Germany\))Tj
4.3256 0 Td
(were)Tj
2.1203 0 Td
(carried)Tj
3.0387 0 Td
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1.5534 0 Td
(on)Tj
1.2756 0 Td
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2.194 0 Td
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(obtained)Tj
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(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(];)Tj
3.2541 0 Td
(2\))Tj
1.0318 0 Td
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3.7757 0 Td
(TBM)Tj
2.3074 0 Td
(\(clinical)Tj
3.4129 0 Td
(features)Tj
3.3505 0 Td
(of)Tj
1.0148 0 Td
(meningitis,)Tj
4.7112 0 Td
(a)Tj
0.652 0 Td
(lumbar)Tj
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(puncture)Tj
3.8608 0 Td
(\(LP\))Tj
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(consistent)Tj
-32.4905 -1.2983 Td
(with)Tj
1.9955 0 Td
(an)Tj
1.2019 0 Td
(aseptic)Tj
2.948 0 Td
(meningitis,)Tj
4.7112 0 Td
(negative)Tj
3.5319 0 Td
(for)Tj
1.389 0 Td
(other)Tj
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(causes)Tj
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(of)Tj
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(meningitis,)Tj
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(and)Tj
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(two)Tj
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(of)Tj
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(the)Tj
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(following:)Tj
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(chest)Tj
2.2506 0 Td
(X-ray)Tj
2.4832 0 Td
(consistent)Tj
4.2576 0 Td
(with)Tj
2.0012 0 Td
(active)Tj
2.5172 0 Td
(pulmonary)Tj
4.6488 0 Td
(tuberculosis)Tj
5.0399 0 Td
(\(PTB\),)Tj
2.8744 0 Td
(a)Tj
0.6576 0 Td
(CT)Tj
1.491 0 Td
(scan)Tj
1.9899 0 Td
(consistent)Tj
4.2576 0 Td
(with)Tj
-34.469 -1.2983 Td
(TBM)Tj
2.3017 0 Td
(\(basal)Tj
2.5455 0 Td
(enhancement)Tj
5.6352 0 Td
(or)Tj
1.0998 0 Td
(hydrocephalus)Tj
6.0718 0 Td
(and)Tj
1.7291 0 Td
(a)Tj
0.652 0 Td
(response)Tj
3.736 0 Td
(to)Tj
1.0205 0 Td
(anti-tuberculous)Tj
6.8428 0 Td
(therapy\))Tj
-31.6344 -1.2983 Td
(\(n)Tj
1.1055 0 Td
(=)Tj
0.7993 0 Td
(46)Tj
1.1736 0 Td
(with)Tj
1.9955 0 Td
(33)Tj
1.1736 0 Td
(ART-naive\);)Tj
5.1817 0 Td
(and)Tj
1.7291 0 Td
(3\))Tj
1.0375 0 Td
(non-TBM)Tj
4.2576 0 Td
(\(an)Tj
1.542 0 Td
(alternate)Tj
3.6964 0 Td
(definite)Tj
3.2655 0 Td
(cause)Tj
2.3867 0 Td
(for)Tj
1.389 0 Td
(meningitis)Tj
4.4844 0 Td
(iden-)Tj
-35.2174 -1.3039 Td
(tified)Tj
2.2903 0 Td
(and)Tj
1.7292 0 Td
(response)Tj
3.736 0 Td
(to)Tj
1.0261 0 Td
(appropriate)Tj
4.8756 0 Td
(non-tuberculous)Tj
6.8938 0 Td
(therapy\))Tj
3.5886 0 Td
(\(n)Tj
1.1112 0 Td
(=)Tj
0.7994 0 Td
(35)Tj
1.1678 0 Td
(with)Tj
2.0013 0 Td
(22)Tj
1.1679 0 Td
(ART-naive\).)Tj
-30.3872 -1.2982 Td
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3.5773 0 Td
(description)Tj
4.7281 0 Td
(and)Tj
1.7348 0 Td
(detection)Tj
3.9345 0 Td
(methods)Tj
3.685 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(non-TBM)Tj
4.2576 0 Td
(group)Tj
2.6079 0 Td
(opportunistic)Tj
5.6295 0 Td
(infections)Tj
-33.012 -1.2983 Td
(are)Tj
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(described)Tj
4.0535 0 Td
(in)Tj
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(previous)Tj
3.651 0 Td
(publications)Tj
5.1193 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
3.2542 0 Td
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3.0784 0 Td
(the)Tj
1.4683 0 Td
(non-TBM)Tj
4.2576 0 Td
(group)Tj
2.6079 0 Td
(consisted)Tj
3.9401 0 Td
(of)Tj
-33.9134 -1.3039 Td
(patients)Tj
3.3675 0 Td
(positive)Tj
3.3165 0 Td
(for)Tj
1.3833 0 Td
(cytomegalovirus)Tj
6.7804 0 Td
(\(CMV\),)Tj
3.3789 0 Td
(herpes)Tj
2.846 0 Td
(simplex)Tj
3.3165 0 Td
(virus)Tj
2.2053 0 Td
(\(HSV)Tj
2.4945 0 Td
(type)Tj
1.9162 0 Td
(1\))Tj
1.0318 0 Td
(varicella)Tj
3.5206 0 Td
(zos-)Tj
-35.5575 -1.2983 Td
(ter)Tj
1.3095 0 Td
(virus)Tj
2.2054 0 Td
(\(VZV\))Tj
2.8913 0 Td
(detected)Tj
3.566 0 Td
(by)Tj
1.1792 0 Td
(viral)Tj
1.9956 0 Td
(PCR)Tj
2.0636 0 Td
(\(Roche)Tj
3.0614 0 Td
(Amplicor\),)Tj
4.6204 0 Td
(neurosyphilis)Tj
5.6012 0 Td
(was)Tj
1.7008 0 Td
(detected)Tj
3.566 0 Td
(by)Tj
1.1792 0 Td
(fluo-)Tj
-34.9396 -1.2982 Td
(rescent)Tj
3.067 0 Td
(treponemal)Tj
4.8132 0 Td
(antibody)Tj
3.7644 0 Td
(\(FTA\))Tj
2.7212 0 Td
(test)Tj
1.5988 0 Td
(and)Tj
1.7348 0 Td
(venereal)Tj
3.5433 0 Td
(disease)Tj
3.016 0 Td
(research)Tj
3.5546 0 Td
(laboratory)Tj
4.354 0 Td
(\(VDRL\))Tj
3.4923 0 Td
(test)Tj
-35.6596 -1.2983 Td
(if)Tj
0.771 0 Td
(FTA)Tj
2.0466 0 Td
(was)Tj
1.7007 0 Td
(positive;)Tj
3.5377 0 Td
(cysticercal)Tj
4.3483 0 Td
(enzyme)Tj
3.3052 0 Td
(linked)Tj
2.7269 0 Td
(immunosorbent)Tj
6.7237 0 Td
(assay)Tj
2.2677 0 Td
(\(ELISA\),)Tj
3.7304 0 Td
(and)Tj
1.7348 0 Td
(a)Tj
0.6519 0 Td
(crypto-)Tj
-33.5449 -1.3039 Td
(coccal)Tj
2.6758 0 Td
(antigen)Tj
3.2032 0 Td
(latex)Tj
2.0919 0 Td
(agglutination)Tj
5.5275 0 Td
(test)Tj
1.5988 0 Td
(\(CLAT\))Tj
3.3959 0 Td
(were)Tj
2.1259 0 Td
(also)Tj
1.7632 0 Td
(carried)Tj
3.0387 0 Td
(out)Tj
1.5534 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
3.2541 0 Td
(The)Tj
1.7858 0 Td
(ELISPOT)Tj
-32.0142 -1.2983 Td
(assay)Tj
2.262 0 Td
(\(T-SPOT.TB;)Tj
5.5559 0 Td
(Oxford)Tj
3.1294 0 Td
(Immunotec,)Tj
5.1533 0 Td
(Oxford,)Tj
3.3506 0 Td
(Abingdon,)Tj
4.5014 0 Td
(UK\))Tj
1.9672 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(to)Tj
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(rule)Tj
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(out)Tj
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(latent)Tj
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(TB)Tj
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(infection)Tj
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(in)Tj
1.0374 0 Td
(non-TBM)Tj
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(patients)Tj
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1.0148 0 Td
(detailed)Tj
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(a)Tj
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(previous)Tj
3.6454 0 Td
(publication)Tj
4.7678 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
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1.4287 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
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(suspected)Tj
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(meningitis)Tj
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(could)Tj
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(as)Tj
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(any)Tj
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(the)Tj
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(groups)Tj
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(and)Tj
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(4)Tj
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(of)Tj
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(ART-na)Tj
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[()]TJ
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(ve.)Tj
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(74)Tj
1.1735 0 Td
(study)Tj
2.3868 0 Td
(participants)Tj
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(ART-na)Tj
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[()]TJ
/F6 1 Tf
(ve)Tj
4.6034 0 Td
(and)Tj
1.7348 0 Td
(29)Tj
1.1679 0 Td
(were)Tj
2.126 0 Td
(ART-exposed)Tj
-30.5913 -1.2983 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
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1.7858 0 Td
(participants)Tj
4.9549 0 Td
(on)Tj
1.2756 0 Td
(ART)Tj
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(were)Tj
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(all)Tj
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(first)Tj
1.8029 0 Td
(line)Tj
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(regimen)Tj
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(recommended)Tj
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(the)Tj
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(South)Tj
-34.5314 -1.3039 Td
(African)Tj
3.2371 0 Td
(Antiretroviral)Tj
5.76 0 Td
(Treatment)Tj
4.4503 0 Td
(Guidelines,)Tj
4.7509 0 Td
(which)Tj
2.6532 0 Td
(includes)Tj
3.5433 0 Td
(two)Tj
1.7121 0 Td
(nucleoside)Tj
4.473 0 Td
(reverse)Tj
3.0501 0 Td
(transcrip-)Tj
-33.63 -1.2983 Td
(tase)Tj
1.7347 0 Td
(inhibitors)Tj
4.1443 0 Td
(\(NRTI\))Tj
3.2088 0 Td
(and)Tj
1.7291 0 Td
(one)Tj
1.7008 0 Td
(non-nucleoside)Tj
6.4289 0 Td
(reverse)Tj
3.0501 0 Td
(transcriptase)Tj
5.3291 0 Td
(inhibitor)Tj
3.7814 0 Td
(\(NNRTI\))Tj
3.9458 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
-35.053 -1.2983 Td
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3.787 0 Td
(1A)Tj
1.3833 0 Td
(consists)Tj
3.3449 0 Td
(of)Tj
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(stavudine)Tj
4.0648 0 Td
(lamivudine)Tj
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(and)Tj
1.7291 0 Td
(efavirenz;)Tj
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(and)Tj
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(regimen)Tj
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(1B)Tj
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(a)Tj
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(combination)Tj
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(of)Tj
1.0147 0 Td
(stavudine,)Tj
4.286 0 Td
(lamivudine)Tj
4.7395 0 Td
(and)Tj
1.7291 0 Td
(nevirapine.)Tj
4.6998 0 Td
(Routine)Tj
3.4129 0 Td
(CD4)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 417.6 360.8503 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(+)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 424.1196 356.4283 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(T-cell)Tj
2.5228 0 Td
(counts)Tj
2.8856 0 Td
(and)Tj
1.7291 0 Td
(clinical)Tj
3.0784 0 Td
(chemistry)Tj
-32.6264 -1.3039 Td
(assays)Tj
2.6248 0 Td
(performed)Tj
4.4674 0 Td
(included)Tj
3.7134 0 Td
(CSF)Tj
1.8878 0 Td
(glucose,)Tj
3.3959 0 Td
(lymphocyte)Tj
4.8926 0 Td
(counts)Tj
2.8912 0 Td
(and)Tj
1.7291 0 Td
(protein)Tj
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(levels)Tj
2.3755 0 Td
(as)Tj
1.0148 0 Td
(previously)Tj
-32.1446 -1.2982 Td
(described)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
2.0749 0 Td
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3.0728 0 Td
(samples)Tj
3.3845 0 Td
(were)Tj
2.1203 0 Td
(aliquoted)Tj
3.9572 0 Td
(and)Tj
1.7348 0 Td
(stored)Tj
2.7041 0 Td
(at)Tj
0.9524 0 Td
(-80C)Tj
2.5795 0 Td
(and)Tj
1.7292 0 Td
(thawed)Tj
3.1181 0 Td
(once)Tj
2.1203 0 Td
(at)Tj
0.9524 0 Td
(use.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 301.7196 cm
BT
/F12 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Viral)Tj
2.3574 0 Td
(loads)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 284.7118 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Plasma)Tj
3.0727 0 Td
(and)Tj
1.7291 0 Td
(CSF)Tj
1.8879 0 Td
(HIV-1)Tj
2.8459 0 Td
(viral)Tj
1.9956 0 Td
(RNA)Tj
2.262 0 Td
(copies)Tj
2.7213 0 Td
(were)Tj
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(quantified)Tj
4.3086 0 Td
(using)Tj
2.3925 0 Td
(the)Tj
1.4683 0 Td
(COBAS)Tj
3.3675 0 Td
(TaqMan)Tj
3.6454 0 Td
(HIV-1)Tj
-33.8171 -1.3039 Td
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2.1373 0 Td
(v2.0,)Tj
2.0749 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(dynamic)Tj
3.6964 0 Td
(detection)Tj
3.9344 0 Td
(range)Tj
2.4662 0 Td
(of)Tj
1.0148 0 Td
(34)Tj
1.1678 0 Td
(to)Tj
1.0262 0 Td
(10,000,000)Tj
4.4787 0 Td
(copies/ml)Tj
4.1159 0 Td
(\(Roche)Tj
3.0614 0 Td
(Molecular)Tj
-31.8272 -1.2982 Td
(Systems,)Tj
3.6396 0 Td
(Inc.)Tj
1.7575 0 Td
(Branchburg,)Tj
5.1987 0 Td
(NJ,)Tj
1.5137 0 Td
(USA\).)Tj
2.6815 0 Td
(The)Tj
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