Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

Wong, Joshua LC; Mason, Alexina J; Gordon, Anthony C; Brett, Stephen J; (2018) Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size? BMJ open, 8 (8). e020068-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2017-020068

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