A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

O'Neill, PM; Amewu, RK; Charman, SA; Sabbani, S; Gnädig, NF; Straimer, J; Fidock, DA; Shore, ER; Roberts, NL; Wong, MH; +38 more... Hong, WD; Pidathala, C; Riley, C; Murphy, B; Aljayyoussi, G; Gamo, FJ; Sanz, L; Rodrigues, J; Cortes, CG; Herreros, E; Angulo-Barturén, I; Jiménez-Díaz, MB; Bazaga, SF; Martínez-Martínez, MS; Campo, B; Sharma, R; Ryan, E; Shackleford, DM; Campbell, S; Smith, DA; Wirjanata, G; Noviyanti, R; Price, RN; Marfurt, J; Palmer, MJ; Copple, IM; Mercer, AE; Ruecker, A; Delves, MJ; Sinden, RE; Siegl, P; Davies, J; Rochford, R; Kocken, CHM; Zeeman, AM; Nixon, GL; Biagini, GA; Ward, SA; (2017) A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature communications, 8. p. 15159. ISSN 2041-1723 DOI: https://doi.org/10.1038/ncomms15159

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