Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia.
Girija
Ramakrishnan
;
Marcia
Wright
;
Masud
Alam
;
Caitlin
Naylor
;
Mamun
Kabir
;
Ayesha
Zerin
;
Tahsin
Ferdous
;
Karl
Pedersen
;
Branwen J
Hennig
;
Jeffrey R
Donowitz
;
+5 more...
Rita
Wegmuller
;
Rashidul
Haque
;
William A
Petri
;
Joel
Herbein
;
Carol A
Gilchrist
;
(2016)
Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia.
Diagnostic microbiology and infectious disease, 87 (3).
pp. 272-274.
ISSN 0732-8893
DOI: 10.1016/j.diagmicrobio.2016.11.011
(In Press)
We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1IU/mL.
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picture_as_pdf - 1-s2.0-S0732889316303947-main.pdf
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subject - Accepted Version
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- Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 3.0
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