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Number of items: 44.

2017

Brand, S; Ko, EJ; Viayna, E; Thompson, S; Spinks, D; Thomas, M; Sandberg, L; Francisco, AF; Jayawardhana, S; Smith, VC; +26 more... (2017) Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi. Journal of medicinal chemistry. ISSN 0022-2623 DOI: 10.1021/acs.jmedchem.7b00463
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Thompson, AM; O'Connor, PD; Marshall, AJ; Yardley, V; Maes, L; Gupta, S; Launay, D; Braillard, S; Chatelain, E; Franzblau, SG; +5 more... (2017) 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. Journal of medicinal chemistry, 60 (10). pp. 4212-4233. ISSN 0022-2623 DOI: 10.1021/acs.jmedchem.7b00034 Full text not available from this repository.

2016

Neves, BJ; Dantas, RF; Senger, MR; Melo-Filho, CC; Valente, WC; de Almeida, AC; Rezende-Neto, JM; Lima, EF; Paveley, R; Furnham, N; +6 more... (2016) Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening. Journal of medicinal chemistry, 59 (15). pp. 7075-88. ISSN 0022-2623 DOI: 10.1021/acs.jmedchem.5b02038 Full text not available from this repository.

2014

Olmo, F; Rotger, C; Ramírez-Macías, I; Martínez, L; Marín, C; Carreras, L; Urbanová, K; Vega, M; Chaves-Lemaur, G; Sampedro, A; +3 more... (2014) Synthesis and biological evaluation of N,N'-squaramides with high in vivo efficacy and low toxicity: toward a low-cost drug against Chagas disease. Journal of medicinal chemistry, 57 (3). pp. 987-99. ISSN 0022-2623 DOI: 10.1021/jm4017015 Full text not available from this repository.

2012

Sánchez-Moreno, M; Gómez-Contreras, F; Navarro, P; Marín, C; Olmo, F; Yunta, MJ; Sanz, AM; Rosales, MJ; Cano, C; Campayo, L; (2012) Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection. Journal of medicinal chemistry, 55 (22). pp. 9900-13. ISSN 0022-2623 DOI: 10.1021/jm3011004 Full text not available from this repository.

Sánchez-Moreno, M; Marín, C; Navarro, P; Lamarque, L; García-España, E; Miranda, C; Huertas, O; Olmo, F; Gómez-Contreras, F; Pitarch, J; +1 more... (2012) In vitro and in vivo trypanosomicidal activity of pyrazole-containing macrocyclic and macrobicyclic polyamines: their action on acute and chronic phases of Chagas disease. Journal of medicinal chemistry, 55 (9). pp. 4231-43. ISSN 0022-2623 DOI: 10.1021/jm2017144 Full text not available from this repository.

2011

Sánchez-Moreno, M; Sanz, AM; Gómez-Contreras, F; Navarro, P; Marín, C; Ramírez-Macias, I; Rosales, MJ; Olmo, F; Garcia-Aranda, I; Campayo, L; +3 more... (2011) In vivo trypanosomicidal activity of imidazole- or pyrazole-based benzo[g]phthalazine derivatives against acute and chronic phases of Chagas disease. Journal of medicinal chemistry, 54 (4). pp. 970-9. ISSN 0022-2623 DOI: 10.1021/jm101198k Full text not available from this repository.

2010

Maldonado, CR; Marín, C; Olmo, F; Huertas, O; Quirós, M; Sánchez-Moreno, M; Rosales, MJ; Salas, JM; (2010) In vitro and in vivo trypanocidal evaluation of nickel complexes with an azapurine derivative against Trypanosoma cruzi. Journal of medicinal chemistry, 53 (19). pp. 6964-72. ISSN 0022-2623 DOI: 10.1021/jm100581z Full text not available from this repository.

Pacorel, B; Leung, SC; Stachulski, AV; Davies, J; Vivas, L; Lander, H; Ward, SA; Kaiser, M; Brun, R; O'Neill, PM; (2010) Modular Synthesis and in Vitro and in Vivo Antimalarial Assessment of C-10 Pyrrole Mannich Base Derivatives of Artemisinin. Journal of medicinal chemistry, 53 (2). pp. 633-640. ISSN 0022-2623 DOI: 10.1021/jm901216v Full text not available from this repository.

Yang, M; Arai, C; Md, AB; Lu, J; Ge, JF; Pudhom, K; Takasu, K; Kasai, K; Kaiser, M; Brun, R; +3 more... (2010) Fluorinated Rhodacyanine (SJL-01) Possessing High Efficacy for Visceral Leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373. ISSN 0022-2623 DOI: 10.1021/jm9013086 Full text not available from this repository.

2009

Gemma, S; Campiani, G; Butini, S; Joshi, BP; Kukreja, G; Coccone, SS; Bernetti, M; Persico, M; Nacci, V; Fiorini, I; +14 more... (2009) Combining 4-Aminoquinoline- and Clotrimazole-Based Pharmacophores toward Innovative and Potent Hybrid Antimalarials. Journal of medicinal chemistry, 52 (2). pp. 502-513. ISSN 0022-2623 DOI: 10.1021/jm801352s Full text not available from this repository.

O'Neill, PM; Shone, AE; Stanford, D; Nixon, G; Asadollahy, E; Park, BK; Maggs, JL; Roberts, P; Stocks, PA; Biagini, G; +19 more... (2009) Synthesis, Antimalarial Activity, and Preclinical Pharmacology of a Novel Series of 4'-Fluoro and 4'-Chloro Analogues of Amodiaquine. Identification of a Suitable "Back-Up" Compound for N-tert-Butyl Isoquine. Journal of medicinal chemistry, 52 (7). pp. 1828-44. ISSN 0022-2623 DOI: 10.1021/jm8012757 Full text not available from this repository.

2008

Ellis, GL; Amewu, R; Sabbani, S; Stocks, PA; Shone, A; Stanford, D; Gibbons, P; Davies, J; Vivas, L; Charnaud, S; +8 more... (2008) Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. Journal of medicinal chemistry, 51 (7). pp. 2170-2177. ISSN 0022-2623 Full text not available from this repository.

Ellis, GL; Amewu, R; Sabbani, S; Stocks, PA; Shone, A; Stanford, D; Gibbons, P; Davies, J; Vivas, L; Charnaud, S; +8 more... (2008) Two-Step Synthesis of Achiral Dispiro-1,2,4,5-tetraoxanes with Outstanding Antimalarial Activity, Low Toxicity, and High-Stability Profiles. Journal of medicinal chemistry, 51 (7). pp. 2170-7. ISSN 0022-2623 DOI: 10.1021/jm701435h Full text not available from this repository.

Fakih, S; Podinovskaia, M; Kong, X; Collins, HL; Schaible, UE; Hider, RC; (2008) Targeting the lysosome: Fluorescent iron(III) chelators to selectively monitor endosomal/lysosomal labile iron pools. Journal of medicinal chemistry, 51 (15). pp. 4539-4552. ISSN 0022-2623 DOI: 10.1021/jm8001247 Full text not available from this repository.

Fattorusso, C; Campiani, G; Kukreja, G; Persico, M; Butini, S; Romano, MP; Altarelli, M; Rost, S; Brindisi, M; Savini, L; +10 more... (2008) Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. Journal of medicinal chemistry, 51 (5). pp. 1333-1343. ISSN 0022-2623 DOI: 10.1021/jm7012375 Full text not available from this repository.

Friebolin, W; Jannack, B; Wenzel, N; Furrer, J; Oeser, T; Sanchez, CP; Lanzer, M; Yardley, V; Becker, K; Davioud-Charvet, E; (2008) Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 51 (5). pp. 1260-1277. ISSN 0022-2623 DOI: 10.1021/jm7009292 Full text not available from this repository.

Gemma, S; Campiani, G; Butini, S; Kukreja, G; Coccone, SS; Joshi, BP; Persico, M; Nacci, V; Fiorini, I; Novellino, E; +12 more... (2008) Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: Design, synthesis, and biological and structure-activity relationship studies. Journal of medicinal chemistry, 51 (5). pp. 1278-1294. ISSN 0022-2623 DOI: 10.1021/jm701247k Full text not available from this repository.

Papanastasiou, I; Tsotinis, A; Kolocouris, N; Prathalingam, SR; Kelly, JM; (2008) Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives. Journal of medicinal chemistry, 51 (5). pp. 1496-1500. ISSN 0022-2623 DOI: 10.1021/jm7014292 Full text not available from this repository.

2007

Gemma, S; Campiani, G; Butini, S; Kukreja, G; Joshi, BP; Persico, M; Catalanotti, B; Novellino, E; Fattorusso, E; Nacci, V; +6 more... (2007) Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. Journal of medicinal chemistry, 50 (4). pp. 595-8. ISSN 0022-2623 DOI: 10.1021/jm061429p Full text not available from this repository.

2006

Gros, L; Lorente, SO; Jimenez, CJ; Yardley, V; Rattray, L; Wharton, H; Little, S; Croft, SL; Ruiz-Perez, LM; Gonzalez-Pacanowska, D; +1 more... (2006) Evaluation of Azasterols as Anti-Parasitics. Journal of medicinal chemistry, 49 (20). pp. 6094-6103. ISSN 0022-2623 DOI: 10.1021/jm060290f Full text not available from this repository.

Hudock, MP; Sanz-Rodriguez, CE; Song, YC; Chan, JMW; Zhang, YH; Odeh, S; Kosztowski, T; Leon-Rossell, A; Concepcion, JL; Yardley, V; +3 more... (2006) Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. Journal of medicinal chemistry, 49 (1). pp. 215-223. ISSN 0022-2623 DOI: 10.1021/jm0582625 Full text not available from this repository.

Stachulski, AV; Berry, NG; Lilian Low, AC; Moores, SL; Row, E; Warhurst, DC; Adagu, IS; Rossignol, JF; (2006) Identification of Isoflavone Derivatives as Effective Anticryptosporidial Agents in Vitro and in Vivo. Journal of medicinal chemistry, 49 (4). pp. 1450-4. ISSN 0022-2623 DOI: 10.1021/jm050973f Full text not available from this repository.

2005

Baliani, A; Bueno, GJ; Stewart, ML; Yardley, V; Brun, R; Barrett, MP; Gilbert, IH; (2005) Design and Synthesis of a Series of Melamine-based Nitroheterocycles with Activity against Trypanosomatid Parasites. Journal of medicinal chemistry, 48 (17). pp. 5570-5579. ISSN 0022-2623 DOI: 10.1021/jm050177+ Full text not available from this repository.

Ersmark, K; Nervall, M; Hamelink, E; Janka, LK; Clemente, JC; Dunn, BM; Blackman, MJ; Samuelsson, B; Aqvist, J; Hallberg, A; (2005) Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. Journal of medicinal chemistry, 48 (19). pp. 6090-106. ISSN 0022-2623 DOI: 10.1021/jm050463l Full text not available from this repository.

Johansson, PO; Lindberg, J; Blackman, MJ; Kvarnström, I; Vrang, L; Hamelink, E; Hallberg, A; Rosenquist, A; Samuelsson, B; (2005) Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II. Journal of medicinal chemistry, 48 (13). pp. 4400-9. ISSN 0022-2623 DOI: 10.1021/jm040884n Full text not available from this repository.

Lee, B; Bauer, H; Melchers, J; Ruppert, T; Rattray, L; Yardley, V; Davioud-Charvet, E; Krauth-Siegel, RL; (2005) Irreversible Inactivation of Trypanothione Reductase by Unsaturated Mannich Bases: A Divinyl Ketone as Key Intermediate. Journal of medicinal chemistry, 48 (23). pp. 7400-7410. ISSN 0022-2623 DOI: 10.1021/jm0504860 Full text not available from this repository.

Onyeibor, O; Croft, SL; Dodson, HI; Feiz-Haddad, M; Kendrick, H; Millington, NJ; Parapini, S; Phillips, RM; Seville, S; Shnyder, SD; +2 more... (2005) Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. Journal of medicinal chemistry, 48 (7). pp. 2701-9. ISSN 0022-2623 DOI: 10.1021/jm040893w Full text not available from this repository.

2004

Ersmark, K; Feierberg, I; Bjelic, S; Hamelink, E; Hackett, F; Blackman, MJ; Hultén, J; Samuelsson, B; Aqvist, J; Hallberg, A; (2004) Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. Journal of medicinal chemistry, 47 (1). pp. 110-22. ISSN 0022-2623 DOI: 10.1021/jm030933g Full text not available from this repository.

Ghosh, S; Chan, JMW; Lea, CR; Meints, GA; Lewis, JC; Tovian, ZS; Flessner, RM; Loftus, TC; Bruchhaus, I; Kendrick, H; +5 more... (2004) Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. Journal of medicinal chemistry, 47 (1). pp. 175-187. ISSN 0022-2623 DOI: 10.1021/jm030084x Full text not available from this repository.

Johansson, PO; Chen, Y; Belfrage, AK; Blackman, MJ; Kvarnström, I; Jansson, K; Vrang, L; Hamelink, E; Hallberg, A; Rosenquist, A; +1 more... (2004) Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs. Journal of medicinal chemistry, 47 (13). pp. 3353-66. ISSN 0022-2623 DOI: 10.1021/jm031106i Full text not available from this repository.

Mantyla, A; Garnier, T; Rautio, R; Nevalainen, T; Vepsalainen, J; Koskinen, A; Croft, SL; Jarvinen, T; (2004) Synthesis, in vitro evaluation, and antileishmanial activity of water-soluble prodrugs of buparvaquone. Journal of medicinal chemistry, 47 (1). pp. 188-195. ISSN 0022-2623 DOI: 10.1021/jm030868a Full text not available from this repository.

Ohkanda, J; Buckner, FS; Lockman, JW; Yokoyama, K; Carrico, D; Eastman, R; de Luca-Fradley, K; Davies, W; Croft, SL; van Voorhis, WC; +3 more... (2004) Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents. Journal of medicinal chemistry. pp. 432-445. ISSN 0022-2623 DOI: 10.1021/jm030236o Full text not available from this repository.

2003

Chauviere, G; Bouteille, B; Enanga, B; de Albuquerque, C; Croft, SL; Dumas, M; Perie, J; (2003) Synthesis and biological activity of nitro heterocycles analogous to megazol, a trypanocidal lead. Journal of medicinal chemistry, 46 (3). pp. 427-440. ISSN 0022-2623 DOI: 10.1021/jm021030a Full text not available from this repository.

Magaraci, F; Jimenez, CJ; Rodrigues, C; Rodrigues, JCF; Braga, MV; Yardley, V; de Luca-Fradley, K; Croft, SL; de Souza, W; Ruiz-Perez, LM; +3 more... (2003) Azasterols as inhibitors of sterol 24-methyltransferase in leishmania species and Trypanosoma cruzi. Journal of medicinal chemistry, 46 (22). pp. 4714-4727. ISSN 0022-2623 DOI: 10.1021/jm021114j Full text not available from this repository.

2002

Jung, MK; Lee, K; Kendrick, H; Robinson, BL; Croft, SL; (2002) Synthesis, stability, and antimalarial activity of new hydrolytically stable and water-soluble (+)-deoxoartelinic acid. Journal of medicinal chemistry, 45 (22). pp. 4940-4. ISSN 0022-2623 DOI: 10.1021/jm020244p Full text not available from this repository.

Martin, MB; Sanders, JM; Kendrick, H; de Luca-Fradley, K; Lewis, JC; Grimley, JS; van Brussel, EM; Olsen, JR; Meints, GA; Burzynska, A; +3 more... (2002) Activity of bisphosphonates against Trypanosoma brucei rhodesiense. Journal of medicinal chemistry, 45 (14). pp. 2904-14. ISSN 0022-2623 DOI: 10.1021/jm0102809 Full text not available from this repository.

2001

Daunes, S; D'Silva, C; Kendrick, H; Yardley, V; Croft, SL; (2001) QSAR study on the contribution of log P and E-s to the in vitro antiprotozoal activity of glutathione derivatives. Journal of medicinal chemistry, 44 (18). pp. 2976-83. ISSN 0022-2623 Full text not available from this repository.

Martin, MB; Grimley, JS; Lewis, JC; Heath, HT; Bailey, BN; Kendrick, H; Yardley, V; Caldera, A; Lira, R; Urbina, JA; +4 more... (2001) Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A potential route to chemotherapy. Journal of medicinal chemistry, 44 (6). pp. 909-16. ISSN 0022-2623 Full text not available from this repository.

Salmon-Chemin, L; Buisine, E; Yardley, V; Kohler, S; Debreu, MA; Landry, V; Sergheraert, C; Croft, SL; Krauth-Siegel, RL; Davioud-Charvet, E; (2001) 2-and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity. Journal of medicinal chemistry, 44 (4). pp. 548-65. ISSN 0022-2623 Full text not available from this repository.

Wright, CW; Addae-Kyereme, J; Breen, AG; Brown, JE; Cox, MF; Croft, SL; Gokcek, Y; Kendrick, H; Phillips, RM; Pollet, PL; (2001) Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. Journal of medicinal chemistry, 44 (19). pp. 3187-94. ISSN 0022-2623 Full text not available from this repository.

This list was generated on Fri Oct 20 11:42:49 2017 BST.