Asres, K; Bucar, F; Knauder, E; Yardley, V; Kendrick, H; Croft, SL; (2001) In vitro antiprotozoal activity of extract and compounds from the stem bark of Combretum molle. Phytotherapy research, 15 (7). pp. 613-7. ISSN 0951-418X http://researchonline.lshtm.ac.uk/id/eprint/16573 Full text not available from this repository.

Baiocco, P; Poce, G; Alfonso, S; Cocozza, M; Porretta, GC; Colotti, G; Biava, M; Moraca, F; Botta, M; Yardley, V; +4 more... Fiorillo, A; Lantella, A; Malatesta, F; Ilari, A; (2013) Inhibition of Leishmania infantum Trypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography. ChemMedChem, 8 (7). pp. 1175-1183. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.201300176 Full text not available from this repository.

Baliani, A; Bueno, GJ; Stewart, ML; Yardley, V; Brun, R; Barrett, MP; Gilbert, IH; (2005) Design and Synthesis of a Series of Melamine-based Nitroheterocycles with Activity against Trypanosomatid Parasites. Journal of medicinal chemistry, 48 (17). pp. 5570-5579. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm050177+ Full text not available from this repository.

Bauer, H; Fritz-Wolf, K; Winzer, A; Kuhner, S; Little, S; Yardley, V; Vezin, H; Palfey, B; Schirmer, RH; Davioud-Charvet, E; (2006) A Fluoro Analogue of the Menadione Derivative 6-[2'-(3'-Methyl)-1',4'-naphthoquinolyl]hexanoic Acid Is a Suicide Substrate of Glutathione Reductase. Crystal Structure of the Alkylated Human Enzyme. Journal of the American Chemical Society, 128 (33). pp. 10784-10794. ISSN 0002-7863 DOI: https://doi.org/10.1021/ja061155v Full text not available from this repository.

Bhambra, AS; Edgar, M; Elsegood, MR; Li, Y; Weaver, GW; Arroo, RR; Yardley, V; Burrell-Saward, H; Krystof, V; (2015) Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes. European journal of medicinal chemistry, 108. pp. 347-353. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2015.11.043 Full text not available from this repository.

Blackie, MAL; Yardley, V; Chibale, K; (2010) Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo. Bioorganic & medicinal chemistry letters, 20 (3). pp. 1078-1080. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2009.12.030 Full text not available from this repository.

Camacho, MD; Phillipson, JD; Croft, SL; Yardley, V; Solis, PN; (2004) In vitro antiprotozoal and cytotoxic activities of some alkaloids, quinones, flavonoids, and coumarins. Planta medica, 70 (1). pp. 70-72. ISSN 0032-0943 DOI: https://doi.org/10.1055/s-2004-815460 Full text not available from this repository.

Carvalho, L; Martínez-García, M; Pérez-Victoria, I; Manzano, JI; Yardley, V; Gamarro, F; Pérez-Victoria, JM; (2015) The oral antimalarial drug tafenoquine shows activity against Trypanosoma brucei. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00879-15 Full text not available from this repository.

Chibale, K; Haupt, H; Kendrick, H; Yardley, V; Saravanamuthu, A; Fairlamb, AH; Croft, SL; (2001) Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine. Bioorganic & medicinal chemistry letters, 11 (19). pp. 2655-2657. ISSN 0960-894X DOI: https://doi.org/10.1016/S0960-894X(01)00528-5 Full text not available from this repository.

Coro, J; Atherton, R; Little, S; Wharton, H; Yardley, V; Alvarez, A; Suarez, M; Perez, R; Rodriguez, H; (2006) Alkyl-linked bis-THTT derivatives as potent in vitro trypanocidal agents. Bioorganic & medicinal chemistry letters, 16 (5). pp. 1312-1315. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2005.11.060 Full text not available from this repository.

Coro, J; Little, S; Yardley, V; Suarez, M; Rodriguez, H; Martin, N; Perez-Pineiro, R; (2008) Synthesis and Antiprotozoal Evaluation of New N-4-(Benzyl)spermidyl-linked bis(1,3,5-thiadiazinane-2-thiones). Archiv der Pharmazie, 341 (11). pp. 708-713. ISSN 0365-6233 DOI: https://doi.org/10.1002/ardp.200800011 Full text not available from this repository.

Croft, SL; Yardley, V; (2002) Chemotherapy of leishmaniasis. Current pharmaceutical design, 8 (4). pp. 319-42. ISSN 1381-6128 DOI: https://doi.org/10.2174/1381612023396258 Full text not available from this repository.

Croft, SL; Yardley, V; Kendrick, H; (2002) Drug sensitivity of Leishmania species: some unresolved problems. Transactions of the Royal Society of Tropical Medicine and Hygiene, 96 Sup. S127-9. ISSN 0035-9203 http://researchonline.lshtm.ac.uk/id/eprint/16578 Full text not available from this repository.

Daunes, S; D'Silva, C; Kendrick, H; Yardley, V; Croft, SL; (2001) QSAR study on the contribution of log P and E-s to the in vitro antiprotozoal activity of glutathione derivatives. Journal of medicinal chemistry, 44 (18). pp. 2976-83. ISSN 0022-2623 http://researchonline.lshtm.ac.uk/id/eprint/16567 Full text not available from this repository.

Decuypere, S; Rijal, S; Yardley, V; de Doncker, S; Laurent, T; Khanal, B; Chappuis, F; Dujardin, JC; (2005) Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal. Antimicrobial agents and chemotherapy, 49 (11). pp. 4616-4621. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.49.11.4616-4621.2005 Full text not available from this repository.

Escobar, P; Yardley, V; Croft, SL; (2001) Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice. Antimicrobial agents and chemotherapy, 45 (6). pp. 1872-5. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.45.6.1872-1875.2001 Full text not available from this repository.

Fattorusso, C; Campiani, G; Kukreja, G; Persico, M; Butini, S; Romano, MP; Altarelli, M; Rost, S; Brindisi, M; Savini, L; +10 more... Novellino, E; Nacci, V; Fattorusso, E; Parapini, S; Basilico, N; Taramelli, D; Yardley, V; Croft, S; Borriello, M; Gemma, S; (2008) Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents. Journal of medicinal chemistry, 51 (5). pp. 1333-1343. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm7012375 Full text not available from this repository.

Ferreira, CL; Ewart, CB; Barta, CA; Little, S; Yardley, V; Martins, C; Polishchuk, E; Smith, PJ; Moss, JR; Merkel, M; +2 more... Adam, MJ; Orvig, C; (2006) Synthesis, Structure, and Biological Activity of Ferrocenyl Carbohydrate Conjugates. Inorganic chemistry, 45 (20). pp. 8414-8422. ISSN 0020-1669 DOI: https://doi.org/10.1021/ic061166p Full text not available from this repository.

Friebolin, W; Jannack, B; Wenzel, N; Furrer, J; Oeser, T; Sanchez, CP; Lanzer, M; Yardley, V; Becker, K; Davioud-Charvet, E; (2008) Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 51 (5). pp. 1260-1277. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm7009292 Full text not available from this repository.

Gemma, S; Campiani, G; Butini, S; Joshi, BP; Kukreja, G; Coccone, SS; Bernetti, M; Persico, M; Nacci, V; Fiorini, I; +14 more... Novellino, E; Taramelli, D; Basilico, N; Parapini, S; Yardley, V; Croft, S; Keller-Maerki, S; Rottmann, M; Brun, R; Coletta, M; Marini, S; Guiso, G; Caccia, S; Fattorusso, C; (2009) Combining 4-Aminoquinoline- and Clotrimazole-Based Pharmacophores toward Innovative and Potent Hybrid Antimalarials. Journal of medicinal chemistry, 52 (2). pp. 502-513. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm801352s Full text not available from this repository.

Gemma, S; Campiani, G; Butini, S; Kukreja, G; Coccone, SS; Joshi, BP; Persico, M; Nacci, V; Fiorini, I; Novellino, E; +12 more... Fattorusso, E; Taglialatela-Scafati, O; Savini, L; Taramelli, D; Basilico, N; Parapini, S; Morace, G; Yardley, V; Croft, S; Coletta, M; Marini, S; Fattorusso, C; (2008) Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: Design, synthesis, and biological and structure-activity relationship studies. Journal of medicinal chemistry, 51 (5). pp. 1278-1294. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm701247k Full text not available from this repository.

Gemma, S; Campiani, G; Butini, S; Kukreja, G; Joshi, BP; Persico, M; Catalanotti, B; Novellino, E; Fattorusso, E; Nacci, V; +6 more... Savini, L; Taramelli, D; Basilico, N; Morace, G; Yardley, V; Fattorusso, C; (2007) Design and Synthesis of Potent Antimalarial Agents Based on Clotrimazole Scaffold: Exploring an Innovative Pharmacophore. Journal of medicinal chemistry, 50 (4). pp. 595-8. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm061429p Full text not available from this repository.

Gemma, S; Kukreja, G; Fattorusso, C; Persico, M; Romano, MP; Altarelli, M; Savini, L; Campiani, G; Fattorusso, E; Basilico, N; +3 more... Taramelli, D; Yardley, V; Butini, S; (2006) Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains. Bioorganic & medicinal chemistry letters, 16 (20). pp. 5384-8. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2006.07.060 Full text not available from this repository.

Gernma, S; Kukreja, G; Campiani, G; Butini, S; Bernetti, M; Joshi, BP; Savini, L; Basifico, N; Taramelli, D; Yardley, V; +5 more... Bertamino, A; Novellino, E; Persico, M; Catalanotti, B; Fattorusso, C; (2007) Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistan P-falciparum strains. Synthesis and molecular modeling. Bioorganic & medicinal chemistry letters, 17 (13). pp. 3535-3539. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2007.04.077 Full text not available from this repository.

Grant, KM; Dunion, MH; Yardley, V; Skaltsounis, AL; Marko, D; Eisenbrand, G; Croft, SL; Meijer, L; Mottram, JC; (2004) Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: Chemical library screen and antileishmanial activity. Antimicrobial agents and chemotherapy, 48 (8). p. 3033. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.48.8.3033-3042.2004 Full text not available from this repository.

Gros, L; Castillo-Acosta, VM; Jimenez Jimenez, C; Sealey-Cardona, M; Vargas, S; Manuel Estevez, A; Yardley, V; Rattray, L; Croft, SL; Ruiz-Perez, LM; +3 more... Urbina, JA; Gilbert, IH; Gonzalez-Pacanowska, D; (2006) New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action. Antimicrobial agents and chemotherapy, 50 (8). pp. 2595-601. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01508-05 Full text not available from this repository.

Gros, L; Lorente, SO; Jimenez, CJ; Yardley, V; Rattray, L; Wharton, H; Little, S; Croft, SL; Ruiz-Perez, LM; Gonzalez-Pacanowska, D; +1 more... Gilbert, IH; (2006) Evaluation of Azasterols as Anti-Parasitics. Journal of medicinal chemistry, 49 (20). pp. 6094-6103. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm060290f Full text not available from this repository.

Guglielmo, S; Bertinaria, M; Rolando, B; Crosetti, M; Fruttero, R; Yardley, V; Croft, SL; Gasco, A; (2009) A new series of amodiaquine analogues modified in the basic side chain with in vitro antileishmanial and antiplasmodial activity. European journal of medicinal chemistry, 44 (12). pp. 5071-5079. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2009.09.012 Full text not available from this repository.

Gupta, S; Yardley, V; Vishwakarma, P; Shivahare, R; Sharma, B; Launay, D; Martin, D; Puri, SK; (2014) Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis. The Journal of antimicrobial chemotherapy. ISSN 0305-7453 DOI: https://doi.org/10.1093/jac/dku422 Full text not available from this repository.

Haque, A; Stanley, AC; Amante, FH; Rivera, FD; Zhou, YH; Kuns, RD; Yardley, V; Sakaguchi, S; Hill, GR; Engwerda, CR; (2010) Therapeutic Glucocorticoid-Induced TNF Receptor-Mediated Amplification of CD4(+) T Cell Responses Enhances Antiparasitic Immunity. Journal of immunology (Baltimore, Md, 184 (5). pp. 2583-2592. ISSN 0022-1767 DOI: https://doi.org/10.4049/jimmunol.0903080 Full text not available from this repository.

Hudock, MP; Sanz-Rodriguez, CE; Song, YC; Chan, JMW; Zhang, YH; Odeh, S; Kosztowski, T; Leon-Rossell, A; Concepcion, JL; Yardley, V; +3 more... Croft, SL; Urbina, JA; Oldfield, E; (2006) Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. Journal of medicinal chemistry, 49 (1). pp. 215-223. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm0582625 Full text not available from this repository.

Jung, M; Lee, K; Jung, H; Kendrick, H; Yardley, V; Croft, SL; (2004) Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives. Bioorganic & medicinal chemistry letters, 14 (8). p. 2001. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2003.12.104 Full text not available from this repository.

Kayser, O; Olbrich, C; Yardley, V; Kiderlen, AF; Croft, SL; (2003) Formulation of amphotericin B as nanosuspension for oral administration. International journal of pharmaceutics, 254 (1). pp. 73-75. ISSN 0378-5173 DOI: https://doi.org/10.1016/s0378-5173(02)00686-5 Full text not available from this repository.

Khrizman, A; Moulthrop, JS; Little, S; Wharton, H; Yardley, V; Moyna, G; (2007) Synthesis and in vitro protozoocidal activity of diazabicyclic benzotropolone derivatives. Bioorganic & medicinal chemistry letters, 17 (15). pp. 4183-4186. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2007.05.044 Full text not available from this repository.

Khrizman, A; Slack, RD; Remsing, RC; Little, S; Yardley, V; Moyna, G; (2007) Synthesis and In Vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives. Archiv der Pharmazie, 340 (11). pp. 569-576. ISSN 0365-6233 DOI: https://doi.org/10.1002/ardp.200700143 Full text not available from this repository.

Kobarfard, F; Yardley, V; Little, S; Daryaee, F; Chibale, K; (2011) Synthesis of Aminoquinoline-based Aminoalcohols and Oxazolidinones and Their Antiplasmodial Activity. Chemical biology & drug design. ISSN 1747-0277 http://researchonline.lshtm.ac.uk/id/eprint/19762 Full text not available from this repository.

Kobarfard, F; Yardley, V; Little, S; Daryaee, F; Chibale, K; (2011) Synthesis of Aminoquinoline-based Aminoalcohols and Oxazolidinones and Their Antiplasmodial Activity. Chemical biology & drug design. ISSN 1747-0277 DOI: https://doi.org/10.1111/j.1747-0285.2011.01278.x Full text not available from this repository.

Larabi, M; Yardley, V; Loiseau, PM; Appel, M; Legrand, P; Gulik, A; Bories, C; Croft, SL; Barratt, G; (2003) Toxicity and Antileishmanial Activity of a New Stable Lipid Suspension of Amphotericin B. Antimicrobial agents and chemotherapy, 47 (12). pp. 3774-3779. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.47.12.3774-3779.2003 Full text not available from this repository.

Laurent, T; Rijal, S; Yardley, V; Croft, S; De Doncker, S; Decuypere, S; Khanal, B; Singh, R; Schönian, G; Kuhls, K; +2 more... Chappuis, F; Dujardin, JC; (2006) Epidemiological dynamics of antimonial resistance in Leishmania donovani: Genotyping reveals a polyclonal population structure among naturally-resistant clinical isolates from Nepal. Infection, genetics and evolution, 7 (2). pp. 206-12. ISSN 1567-1348 DOI: https://doi.org/10.1016/j.meegid.2006.08.005 Full text not available from this repository.

Lawn, SD; Yardley, V; Vega-Lopez, F; Watson, J; Lockwood, DN; (2003) New World cutaneous leishmaniasis in returned travellers: treatment failures using intravenous sodium stibogluconate. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97 (4). p. 443. ISSN 0035-9203 DOI: https://doi.org/10.1016/S0035-9203(03)90084-8 Full text not available from this repository.

Lee, B; Bauer, H; Melchers, J; Ruppert, T; Rattray, L; Yardley, V; Davioud-Charvet, E; Krauth-Siegel, RL; (2005) Irreversible Inactivation of Trypanothione Reductase by Unsaturated Mannich Bases: A Divinyl Ketone as Key Intermediate. Journal of medicinal chemistry, 48 (23). pp. 7400-7410. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm0504860 Full text not available from this repository.

Les, KA; Mohamed-Ahmed, AHA; Balan, S; Choi, J.-, W; Martin, D; Yardley, V; Powell, K; Godwin, A; Brocchini, S; (2014) Poly(methacrylic acid) complexation of amphotericin B to treat neglected diseases. Polymer chemistry, 5 (3). pp. 1037-1048. ISSN 1759-9954 DOI: https://doi.org/10.1039/c3py01051a Full text not available from this repository.

Lorente, SO; Gomez, R; Jimenez, C; Cammerer, S; Yardley, V; de Luca-Fradley, K; Croft, SL; Perez, LMR; Urbina, J; Pacanowska, DG; +1 more... Gilbert, IH; (2005) Biphenylquinuclidines as inhibitors of squalene synthase and growth of parasitic protozoa. Bioorganic & medicinal chemistry, 13 (10). pp. 3519-3529. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2005.02.060 Full text not available from this repository.

Lorente, SO; Jimenez, CJ; Gros, L; Yardley, V; de Luca-Fradley, K; Croft, SL; Urbina, JA; Ruiz-Perez, LM; Pacanowska, DG; Gilbert, IH; (2005) Preparation of transition-state analogues of sterol 24-methyl transferase as potential anti-parasities. Bioorganic & medicinal chemistry, 13 (18). pp. 5435-5453. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2005.06.012 Full text not available from this repository.

Lorente, SO; Rodrigues, JCF; Jimenez, CJ; Joyce-Menekse, M; Rodrigues, C; Croft, SL; Yardley, V; de Luca-Fradley, K; Ruiz-Perez, LM; Urbina, J; +3 more... de Souza, W; Pacanowska, DG; Gilbert, IH; (2004) Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis. Antimicrobial agents and chemotherapy, 48 (8). p. 2937. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.48.8.2937-2950.2004 Full text not available from this repository.

Magaraci, F; Jimenez, CJ; Rodrigues, C; Rodrigues, JCF; Braga, MV; Yardley, V; de Luca-Fradley, K; Croft, SL; de Souza, W; Ruiz-Perez, LM; +3 more... Urbina, J; Pacanowska, DG; Gilbert, IH; (2003) Azasterols as inhibitors of sterol 24-methyltransferase in leishmania species and Trypanosoma cruzi. Journal of medicinal chemistry, 46 (22). pp. 4714-4727. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm021114j Full text not available from this repository.

Martin, MB; Grimley, JS; Lewis, JC; Heath, HT; Bailey, BN; Kendrick, H; Yardley, V; Caldera, A; Lira, R; Urbina, JA; +4 more... Moreno, SNJ; Docampo, R; Croft, SL; Oldfield, E; (2001) Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A potential route to chemotherapy. Journal of medicinal chemistry, 44 (6). pp. 909-16. ISSN 0022-2623 http://researchonline.lshtm.ac.uk/id/eprint/16563 Full text not available from this repository.

Mohamed-Ahmed, AbeerHA; Seifert, Karin; Yardley, Vanessa; Burrell-Saward, Hollie; Brocchini, Stephen; Croft, SimonL; (2013) Antileishmanial Activity, Uptake, and Biodistribution of an Amphotericin B and Poly(alpha-Glutamic Acid) Complex. Antimicrobial agents and chemotherapy, 57 (10). pp. 4608-4614. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02343-12 Full text not available from this repository.

Muller, T; Johann, L; Jannack, B; Bruckner, M; Lanfranchi, DA; Bauer, H; Sanchez, C; Yardley, V; Deregnaucourt, C; Schrevel, J; +3 more... Lanzer, M; Schirmer, RH; Davioud-Charvet, E; (2011) Glutathione Reductase-Catalyzed Cascade of Redox Reactions To Bioactivate Potent Antimalarial 1,4-Naphthoquinones - A New Strategy to Combat Malarial Parasites. Journal of the American Chemical Society, 133 (30). pp. 11557-11571. ISSN 0002-7863 DOI: https://doi.org/10.1021/ja201729z Full text not available from this repository.

Musonda, CC; Gut, J; Rosenthal, PJ; Yardley, V; Carvalho de Souza, RC; Chibale, K; (2006) Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. Bioorganic & medicinal chemistry, 14 (16). pp. 5605-15. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2006.04.035 Full text not available from this repository.

Musonda, CC; Little, S; Yardley, V; Chibale, K; (2007) Application of multicomponent reactions to antimalarial drug discovery. Part 3: Discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro. Bioorganic & medicinal chemistry letters, 17 (17). pp. 4733-4736. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2007.06.070 Full text not available from this repository.

Musonda, CC; Yardley, V; de Souza, RCC; Ncokazi, K; Egan, TJ; Chibale, K; (2008) Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines. Organic & biomolecular chemistry, 6 (23). pp. 4446-4451. ISSN 1477-0520 DOI: https://doi.org/10.1039/b813007h Full text not available from this repository.

Nan, A; Croft, SL; Yardley, V; Ghandehari, H; (2004) Targetable water-soluble polymer-drug conjugates for the treatment of visceral leishmaniasis. Journal of controlled release, 94 (1). pp. 115-127. ISSN 0168-3659 DOI: https://doi.org/10.1016/j.jconrel.2003.09.012 Full text not available from this repository.

Nan, A; Nanayakkara, NPD; Walker, LA; Yardley, V; Croft, SL; Ghandehari, H; (2001) N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmanial drugs. Journal of controlled release, 77 (3). pp. 233-43. ISSN 0168-3659 http://researchonline.lshtm.ac.uk/id/eprint/16572 Full text not available from this repository.

Nanayakkara, NP; Ager, AL; Bartlett, MS; Yardley, V; Croft, SL; Khan, IA; McChesney, JD; Walker, LA; (2008) Antiparasitic activities and toxicities of individual enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichloropheno xy]quinoline succinate. Antimicrobial agents and chemotherapy, 52 (6). pp. 2130-2137. ISSN 0066-4804 DOI: https://doi.org/10.1128/aac.00645-07 Full text not available from this repository.

Nanayakkara, NP; Ager, ALJr; Bartlett, MS; Yardley, V; Croft, SL; Khan, IA; McChesney, JD; Walker, LA; (2008) Antiparasitic Activity and Toxicity of Individual Enantiomers of the 8-Aminoquinoline, 8-[(4-Amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline Succinate. Antimicrobial agents and chemotherapy, 52 (6). pp. 2130-7. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00645-07 Full text not available from this repository.

October, N; Watermeyer, ND; Yardley, V; Egan, TJ; Ncokazi, K; Chibale, K; (2008) Reversed Chloroquines Based on the 3,4-Dihydropyrimidin-2(1H)-one Scaffold: Synthesis and Evaluation for Antimalarial, beta-Haematin Inhibition, and Cytotoxic Activity. ChemMedChem, 3 (11). pp. 1649-1653. ISSN 1860-7179 DOI: https://doi.org/10.1002/cmdc.200800172 Full text not available from this repository.

Parveen, S; Khan, MO; Austin, SE; Croft, SL; Yardley, V; Rock, P; Douglas, KT; (2005) Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. Journal of medicinal chemistry, 48 (25). pp. 8087-97. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm050819t Full text not available from this repository.

Pez, D; Leal, I; Zuccotto, F; Boussard, C; Brun, R; Croft, SL; Yardley, V; Perez, LMR; Pacanowska, DG; Gilbert, IH; (2003) 2,4-diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Bioorganic & medicinal chemistry, 11 (22). pp. 4693-4711. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2003.08.012 Full text not available from this repository.

Peña, S; Scarone, L; Manta, E; Stewart, L; Yardley, V; Croft, S; Serra, G; (2012) Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity. Bioorganic & medicinal chemistry letters, 22 (15). pp. 4994-7. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2012.06.028 Full text not available from this repository.

Ren, HY; Grady, S; Banghart, M; Moulthrop, JS; Kendrick, H; Yardley, V; Croft, SL; Moyna, G; (2003) Synthesis and in vitro anti-protozoal activity of a series of benzotropolone derivatives incorporating endocyclic hydrazines. European journal of medicinal chemistry, 38 (11-12). p. 949. ISSN 0223-5234 DOI: https://doi.org/10.1016/s0223-5234(03)00180-6 Full text not available from this repository.

Ren, HY; Grady, S; Gamenara, D; Heinzen, H; Moyna, P; Croft, SL; Kendrick, H; Yardley, V; Moyna, G; (2001) Design, synthesis, and biological evaluation of a series of simple and novel potential antimalarial compounds. Bioorganic & medicinal chemistry letters, 11 (14). pp. 1851-1854. ISSN 0960-894X DOI: https://doi.org/10.1016/S0960-894X(01)00308-0 Full text not available from this repository.

Rijal, S; Yardley, V; Chappuis, F; Decuypere, S; Khanal, B; Singh, R; Boelaert, M; de Doncker, S; Croft, S; Dujardin, JC; (2007) Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome? Microbes and infection / Institut Pasteur, 9 (4). pp. 529-535. ISSN 1286-4579 DOI: https://doi.org/10.1016/j.micinf.2007.01.009 Full text not available from this repository.

Salmon-Chemin, L; Buisine, E; Yardley, V; Kohler, S; Debreu, MA; Landry, V; Sergheraert, C; Croft, SL; Krauth-Siegel, RL; Davioud-Charvet, E; (2001) 2-and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity. Journal of medicinal chemistry, 44 (4). pp. 548-65. ISSN 0022-2623 http://researchonline.lshtm.ac.uk/id/eprint/16559 Full text not available from this repository.

Sanderson, L; Yardley, V; Croft, SL; (2014) Activity of anti-cancer protein kinase inhibitors against Leishmania spp. The Journal of antimicrobial chemotherapy. ISSN 0305-7453 DOI: https://doi.org/10.1093/jac/dku069 Full text not available from this repository.

Tasdemir, D; Brun, R; Yardley, V; Franzblau, SG; Rüedi, P; (2006) Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies. Chemistry & biodiversity, 3 (11). pp. 1230-7. ISSN 1612-1872 DOI: https://doi.org/10.1002/cbdv.200690124 Full text not available from this repository.

Tasdemir, D; Kaiser, M; Brun, R; Yardley, V; Schmidt, TJ; Tosun, F; Ruedi, P; (2006) Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrobial agents and chemotherapy, 50 (4). pp. 1352-64. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.50.4.1352-1364.2006 Full text not available from this repository.

Too, K; Brown, DM; Bongard, E; Yardley, V; Vivas, L; Loakes, D; (2007) Anti-malarial activity of N-6-modified purine analogues. Bioorganic & medicinal chemistry, 15 (16). pp. 5551-5562. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2007.05.038 Full text not available from this repository.

Van Bocxlaer, K; Yardley, V; Murdan, S; Croft, SL; (2016) Drug permeation and barrier damage in Leishmania-infected mouse skin. The Journal of antimicrobial chemotherapy, 71 (6). pp. 1578-85. ISSN 0305-7453 DOI: https://doi.org/10.1093/jac/dkw012 Full text not available from this repository.

Yang, M; Arai, C; Md, AB; Lu, J; Ge, JF; Pudhom, K; Takasu, K; Kasai, K; Kaiser, M; Brun, R; +3 more... Yardley, V; Itoh, I; Ihara, M; (2010) Fluorinated Rhodacyanine (SJL-01) Possessing High Efficacy for Visceral Leishmaniasis (VL). Journal of medicinal chemistry, 53 (1). pp. 368-373. ISSN 0022-2623 DOI: https://doi.org/10.1021/jm9013086 Full text not available from this repository.

Yardley, V; Gamarro, F; Croft, SL; (2010) Antileishmanial and antitrypanosomal activities of the 8-aminoquinoline tafenoquine. Antimicrobial agents and chemotherapy, 54 (12). pp. 5356-8. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00985-10 Full text not available from this repository.

Yardley, V; Khan, AA; Martin, MB; Slifer, TR; Araujo, FG; Moreno, SN; Docampo, R; Croft, SL; Oldfield, E; (2002) In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrobial agents and chemotherapy, 46 (3). pp. 929-31. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.46.3.929-931.2002 Full text not available from this repository.

Yardley, V; Koniordou, M; (2018) Chapter 4: Drug Assay Methodology in Leishmaniasis: From the Microplate to Image Analysis. In: UNSPECIFIED, (ed.) Drug Discovery for Leishmaniasis. Royal Society of Chemistry, pp. 55-76. ISBN 9781782628897 DOI: https://doi.org/10.1039/9781788010177 Full text not available from this repository.

Yardley, V; Ortuno, N; Llanos-Cuentas, A; Chappuis, F; Doncker, SD; Ramirez, L; Croft, S; Arevalo, J; Adaui, V; Bermudez, H; +2 more... Decuypere, S; Dujardin, JC; (2006) American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility? The Journal of infectious diseases, 194 (8). pp. 1168-75. ISSN 0022-1899 DOI: https://doi.org/10.1086/507710 Full text not available from this repository.

Abazid, Nizar; (2010) Treatment of localised cutaneous Leishmania tropica infection in Aleppo, Syria and drug sensitivity of clinical isolates. PhD thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.01742275

Basilico, N; Parapini, S; Sparatore, A; Romeo, S; Misiano, P; Vivas, L; Yardley, V; Croft, SL; Habluetzel, A; Lucantoni, L; +8 more... Renia, L; Russell, B; Suwanarusk, R; Nosten, F; Dondio, G; Bigogno, C; Jabes, D; Taramelli, D; (2017) In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial. Molecules (Basel, Switzerland), 22 (12). ISSN 1420-3049 DOI: https://doi.org/10.3390/molecules22122102

Bhambra, AS; Ruparelia, KC; Tan, HL; Tasdemir, D; Burrell-Saward, H; Yardley, V; Beresford, KJ; Arroo, RR; (2017) Synthesis and antitrypanosomal activities of novel pyridylchalcones. European journal of medicinal chemistry, 128. pp. 213-218. ISSN 0223-5234 DOI: https://doi.org/10.1016/j.ejmech.2017.01.027

Corware, K; Yardley, V; Mack, C; Schuster, S; Al-Hassi, H; Herath, S; Bergin, P; Modolell, M; Munder, M; Müller, I; +1 more... Kropf, P; (2014) Protein energy malnutrition increases arginase activity in monocytes and macrophages. Nutrition & metabolism, 11 (1). p. 51. ISSN 1743-7075 DOI: https://doi.org/10.1186/1743-7075-11-51

Croft, SL; Seifert, K; Yardley, V; (2006) Current scenario of drug development for leishmaniasis. The Indian journal of medical research, 123 (3). pp. 399-410. ISSN 0971-5916 http://researchonline.lshtm.ac.uk/id/eprint/11722

Daunes, S; Yardley, V; Croft, SL; D'Silva, C; (2016) Antiprotozoal glutathione derivatives with flagellar membrane binding activity against T. brucei rhodesiense. Bioorganic & medicinal chemistry. ISSN 0968-0896 DOI: https://doi.org/10.1016/j.bmc.2016.12.016

Decuypere, S; Vanaerschot, M; Rijal, S; Yardley, V; Maes, L; de Doncker, S; Chappuis, F; Dujardin, JC; (2008) Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation. Parasitology, 135 (2). pp. 183-194. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182007003782

Decuypere, S; Vandesompele, J; Yardley, V; De Donckeri, S; Laurent, T; Rijal, S; Llanos-Cuentas, A; Chappuis, F; Arevalo, J; Dujardin, JC; (2005) Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. Parasitology, 131 (Pt 3). pp. 321-9. ISSN 0031-1820 DOI: https://doi.org/10.1017/s0031182005007808

Guo, M; Wang, K; Qiao, N; Yardley, V; Li, M; (2018) Investigating Permeation Behavior of Flufenamic Acid Cocrystals Using a Dissolution and Permeation System. Molecular pharmaceutics. ISSN 1543-8384 DOI: https://doi.org/10.1021/acs.molpharmaceut.8b00670

Khan, NH; Bari, AU; Hashim, R; Khan, I; Muneer, A; Shah, A; Wahid, S; Yardley, V; O'Neil, B; Sutherland, CJ; (2016) Cutaneous Leishmaniasis in Khyber Pakhtunkhwa Province of Pakistan: Clinical Diversity and Species-Level Diagnosis. The American journal of tropical medicine and hygiene. ISSN 0002-9637 DOI: https://doi.org/10.4269/ajtmh.16-0343

Tegazzini, D; Díaz, R; Aguilar, F; Peña, I; Presa, JL; Yardley, V; Martin, JJ; Coteron, JM; Croft, SL; Cantizani, J; (2016) A replicative in vitro assay for drug discovery against Leishmania donovani. Antimicrobial agents and chemotherapy, 60 (6). pp. 3524-32. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01781-15

Thompson, AM; O'Connor, PD; Blaser, A; Yardley, V; Maes, L; Gupta, S; Launay, D; Martin, D; Franzblau, SG; Wan, B; +3 more... Wang, Y; Ma, Z; Denny, WA; (2016) Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. Journal of medicinal chemistry. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.5b01699

Thompson, AM; O'Connor, PD; Marshall, AJ; Blaser, A; Yardley, V; Maes, L; Gupta, S; Launay, D; Braillard, S; Chatelain, E; +5 more... Wan, B; Franzblau, SG; Ma, Z; Cooper, CB; Denny, WA; (2018) Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis. Journal of medicinal chemistry. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.7b01581

Thompson, AM; O'Connor, PD; Marshall, AJ; Yardley, V; Maes, L; Gupta, S; Launay, D; Braillard, S; Chatelain, E; Franzblau, SG; +5 more... Wan, B; Wang, Y; Ma, Z; Cooper, CB; Denny, WA; (2017) 7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis. Journal of medicinal chemistry, 60 (10). pp. 4212-4233. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.7b00034

Van Bocxlaer, K; Gaukel, E; Hauser, D; Park, SH; Schock, S; Yardley, V; Randolph, R; Plattner, JJ; Merchant, T; Croft, SL; +2 more... Jacobs, RT; Wring, SA; (2018) Topical treatment for cutaneous leishmaniasis - dermato-pharmacokinetic led optimisation of benzoxaboroles. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02419-17

Van Bocxlaer, K; Yardley, V; Murdan, S; Croft, SL; (2016) Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse model. The Journal of pharmacy and pharmacology, 68 (7). pp. 862-72. ISSN 0022-3573 DOI: https://doi.org/10.1111/jphp.12548

Wijnant, GJ; Van Bocxlaer, K; Fortes Francisco, A; Yardley, V; Harris, A; Alavijeh, M; Murdan, S; Croft, SL; (2018) Local skin inflammation in cutaneous leishmaniasis as a source of variable pharmacokinetics and therapeutic efficacy of liposomal amphotericin B. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00631-18

Wijnant, GJ; Van Bocxlaer, K; Yardley, V; Harris, A; Alavijeh, M; Silva-Pedrosa, R; Antunes, S; Mauricio, I; Murdan, S; Croft, SL; (2018) Comparative efficacy, toxicity and biodistribution of the liposomal amphotericin B formulations Fungisome® and AmBisome® in murine cutaneous leishmaniasis. International journal for parasitology Drugs and drug resistance, 8 (2). pp. 223-228. ISSN 2211-3207 DOI: https://doi.org/10.1016/j.ijpddr.2018.04.001

Wijnant, GJ; Van Bocxlaer, K; Yardley, V; Harris, A; Murdan, S; Croft, SL; (2017) AmBisome® treatment of murine cutaneous leishmaniasis: relation between skin pharmacokinetics and efficacy. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.02009-17

Wijnant, GJ; Van Bocxlaer, K; Yardley, V; Murdan, S; Croft, S; (2017) Efficacy of a Paromomycin plus Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis. Antimicrobial agents and chemotherapy. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00358-17

Yardley, V; Croft, SL; DE Doncker, S; Dujardin, JC; Koirala, S; Rijal, S; Miranda, C; Llanos-Cuentas, A; Chappuis, F; (2005) THE SENSITIVITY OF CLINICAL ISOLATES OF LEISHMANIA FROM PERU AND NEPAL TO MILTEFOSINE. The American journal of tropical medicine and hygiene, 73 (2). pp. 272-5. ISSN 0002-9637 http://researchonline.lshtm.ac.uk/id/eprint/13280

Yizengaw, E; Getahun, M; Tajebe, F; Cruz Cervera, E; Adem, E; Mesfin, G; Hailu, A; Van der Auwera, G; Yardley, V; Lemma, M; +10 more... Skhedy, Z; Diro, E; Yeshanew, A; Melkamu, R; Mengesha, B; Modolell, M; Munder, M; Müller, I; Takele, Y; Kropf, P; (2016) Visceral Leishmaniasis Patients Display Altered Composition and Maturity of Neutrophils as well as Impaired Neutrophil Effector Functions. Frontiers in immunology, 7. p. 517. ISSN 1664-3224 DOI: https://doi.org/10.3389/fimmu.2016.00517