Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.
Campbell, Mary S;
Kahle, Erin M;
Celum, Connie;
Lingappa, Jairam R;
Kapiga, Saidi;
Mujugira, Andrew;
Mugo, Nelly R;
Fife, Kenneth H;
Mullins, James I;
Baeten, Jared M;
+1 more...Partners in Prevention HSV/HIV Transmission Study Team;
(2013)
Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.
The Journal of infectious diseases, 207 (7).
pp. 1166-1170.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jit015
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.
