Eight years of hepatitis B vaccination in Colombia with a recombinant vaccine: factors influencing hepatitis B virus infection and effectiveness

de la Hoz, Fernando; Perez, Ligia; de Neira, Marlen; Hall, Andrew J; (2008) Eight years of hepatitis B vaccination in Colombia with a recombinant vaccine: factors influencing hepatitis B virus infection and effectiveness. International journal of infectious diseases, 12 (2). pp. 183-189. ISSN 1201-9712 DOI: https://doi.org/10.1016/j.ijid.2007.06.010

Abstract

Objective: To evaluate the effectiveness of a recombinant hepatitis B vaccine used in endemic areas of Colombia, as well as risk factors associated with hepatitis B virus (HBV) infection and carriage after vaccine introduction. Methods: A cross-sectional study was carried out in urban and rural areas of the Colombian Amazon, a highly endemic area for hepatitis B infection. Children under 12 years of age and their mothers were selected for the study using one-stage cluster sampling (N = 2145) and were examined for HBV serological markers and antibodies against surface antigen (anti-HBs). Results: There has been a reduction of 60-75% in the prevalence of HBV infection and hepatitis B surface antigen (HBsAg) carriage since HBV vaccination was introduced. Receiving the first dose of HBV vaccine at more than two months after birth was one of the factors associated with HBV carrier status. Maternal HBV infection was also associated with infection in the child. Conclusions: The recombinant Cuban hepatitis B vaccine has contributed to the reduction of the infection in this highly endemic area, though further efforts are required to improve timely vaccination for children at high risk. (c) 2007 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.