Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis.

Moss, Alastair J; Sim, Alisia M; Adamson, Philip D; Seidman, Michael A; Andrews, Jack PM; Doris, Mhairi K; Shah, Anoop SV; BouHaidar, Ralph; Alcaide-Corral, Carlos J; Williams, Michelle C; +6 more... Leipsic, Jonathon A; Dweck, Marc R; MacRae, Vicky E; Newby, David E; Tavares, Adriana AS; Sellers, Stephanie L; (2020) Ex vivo 18F-fluoride uptake and hydroxyapatite deposition in human coronary atherosclerosis. SCIENTIFIC REPORTS, 10 (1). 20172-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-020-77391-6

Abstract

Early microcalcification is a feature of coronary plaques with an increased propensity to rupture and to cause acute coronary syndromes. In this ex vivo imaging study of coronary artery specimens, the non-invasive imaging radiotracer, 18F-fluoride, was highly selective for hydroxyapatite deposition in atherosclerotic coronary plaque. Specifically, coronary 18F-fluoride uptake had a high signal to noise ratio compared with surrounding myocardium that makes it feasible to identify coronary mineralisation activity. Areas of 18F-fluoride uptake are associated with osteopontin, an inflammation-associated glycophosphoprotein that mediates tissue mineralisation, and Runt-related transcription factor 2, a nuclear protein involved in osteoblastic differentiation. These results suggest that 18F-fluoride is a non-invasive imaging biomarker of active coronary atherosclerotic mineralisation.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID	33214599
Elements ID	153246