Peçanha, Pedro Massaroni; Gomes Junior, Saint Clair; Pone, Sheila Moura; Pone, Marcos Vinicius da Silva; Vasconcelos, Zilton; Zin, Andrea; Vilibor, Renata Hydee Hasue; Costa, Roozemeria Pereira; Meio, Maria Dalva Barbosa Baker; Nielsen-Saines, Karin; +3 more... Brasil, Patricia; Brickley, Elizabeth; Lopes Moreira, Maria Elisabeth; (2020) Neurodevelopment of children exposed intra-uterus by Zika virus: A case series. PLOS ONE, 15 (2). e0229434-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0229434
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Abstract
The main goal of this manuscript was to investigate the neurodevelopment of children exposed by Zika virus in the intrauterine period who are asymptomatic at birth. Newborns with documented Zika virus exposure during the intrauterine period who were asymptomatic at birth were followed in the first two years of life for neurodevelopment using Bayley III test. Children were classified as having normal or delayed neurodevelopment for age based on most recent Bayley III evaluation results. Eighty-four infants were included in the study. The first Bayley III evaluation was performed at a mean chronological age of 9.7±3.1 month; 13 children (15%) had a delay in one of the three domains, distributed as follow: 10 (12%) in the language domain and 3 (3.5%) in the motor domain. The most recent Bayley III evaluation was performed at a mean age 15.3±3.1 months; 42 children (50%) had a delay in one of the three domains: 4 (5%) in cognition, 31 (37%) in language, and 20 (24%) in motor performance. There were no statistical differences in Gender, Gestational Age, Birth Weight and Head Circurference at birth between children with normal and delayed neurodevelopment for age. A very high proportion of children exposed ZIKV during pregnancy who were asymptomatic at birth demonstrated a delay in neurodevelopment, mainly in the language domain, the first two years of life.
Item Type | Article |
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Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) |
Research Centre |
Centre for Epidemic Preparedness and Response Centre for Maternal, Reproductive and Child Health (MARCH) |
PubMed ID | 32109947 |
Elements ID | 145403 |
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