?-amyloid influences the relationship between cortical thickness and vascular load
Parker, Thomas D;
Cash, David M;
Lane, Christopher A;
Lu, Kirsty;
Malone, Ian B;
Nicholas, Jennifer;
James, Sarah-Naomi;
Keshavan, Ashvini;
Murray-Smith, Heidi;
Wong, Andrew;
+8 more...Buchanan, Sarah M;
Keuss, Sarah E;
Sudre, Carole H;
Thomas, David L;
Crutch, Sebastian J;
Fox, Nick C;
Richards, Marcus;
Schott, Jonathan M;
(2019)
?-amyloid influences the relationship between cortical thickness and vascular load.
Alzheimer's & Dementia Diagnosis, Assessment & Disease Monitoring, 12.
e12022-.
ISSN 2352-8729
DOI: https://doi.org/10.1002/dad2.12022
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Introduction: Cortical thickness has been proposed as a biomarker of Alzheimer�s disease related neurodegeneration, but the nature of its relationship with amyloid (A?) deposition and white matter hyperintensity volume (WMHV) in cognitively normal adults is unclear. Methods: We investigated the influences of A?-status (negative/positive) and WMHV on cortical thickness in 408 cognitively normal adults aged 69.2-71.9 years who underwent 18F-Florbetapir PET and structural MRI. Two previously defined Alzheimer�s disease cortical signature regions and the major cortical lobes were selected as regions of interest for cortical thickness. Results: Higher white matter hyperintensity volume, but not A?-status, predicted lower cortical thickness across all participants, in all regions of interest. Conversely, when A?-positive participants were considered alone, higher white matter hyperintensity volume predicted higher cortical thickness in a temporal Alzheimer�s disease-signature region. Discussion: WMHV may differentially influence cortical thickness depending on the presence or absence of ?-amyloid, potentially reflecting different pathological mechanisms