Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis.

Molloy, Síle F; Bradley, John; Karunaharan, Natasha; Mputu, Muhammad; Stone, Neil; Phulusa, Jacob; Chawinga, Chimwemwe; Gaskell, Kate; Segula, Dalitso; Ming, Damien; +7 more... Peirse, Mary; Chanda, Duncan; Lakhi, Shabir; Loyse, Angela; Kanyama, Cecilia; Heyderman, Robert S; Harrison, Thomas S; (2018) Effect of oral fluconazole 1200 mg/day on QT interval in African adults with HIV-associated cryptococcal meningitis. AIDS (London, England), 32 (15). pp. 2259-2261. ISSN 0269-9370 DOI: https://doi.org/10.1097/QAD.0000000000001961

Abstract

: We assessed the effect of fluconazole 1200 mg/day on the QT interval in cryptococcal meningitis patients. Mean corrected QT (QTc) change from baseline to day 7 was 10.1 ms (IQR: -28 to 46 ms) in the fluconazole treatment group and -12.6 ms (IQR: -39 to 13.5 ms) in those not taking fluconazole (P = 0.04). No significant increase in QTc measurements over 500 ms was observed with fluconazole. Nevertheless, it remains important to correct any electrolyte imbalance and avoid concomitant drugs that may increase QTc.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID	30102652
Related URLs	OA Location