Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda.
Tukwasibwe, Stephen;
Mugenyi, Levi;
Mbogo, George W;
Nankoberanyi, Sheila;
Maiteki-Sebuguzi, Catherine;
Joloba, Moses L;
Nsobya, Samuel L;
Staedke, Sarah G;
Rosenthal, Philip J;
(2014)
Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda.
The Journal of infectious diseases, 210 (1).
pp. 154-157.
ISSN 0022-1899
DOI: https://doi.org/10.1093/infdis/jiu044
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We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children (pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.
