Bojang, Abdoulie; Kendall, Lindsay; Usuf, Effua; Egere, Uzochukwu; Mulwa, Sarah; Antonio, Martin; Greenwood, Brian; Hill, Philip C; Roca, Anna; (2017) Prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage during a PCV trial. BMC infectious diseases, 17 (1). 588-. ISSN 1471-2334 DOI: https://doi.org/10.1186/s12879-017-2685-1
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Abstract
BACKGROUND: We conducted an ancillary study among individuals who had participated in a cluster-randomized PCV-7 trial in rural Gambia (some clusters were wholly-vaccinated while in others only young children had been vaccinated), to determine the prevalence and risk factors for Staphylococcus aureus nasopharyngeal carriage. METHODS: Two hundred thirty-two children aged 5-10 years were recruited and followed from 4 to 20 months after vaccination started. We collected 1264 nasopharyngeal swabs (NPS). S. aureus was isolated following conventional microbiological methods. Risk factors for carriage were assessed by logistic regression. RESULTS: Prevalence of S. aureus carriage was 25.9%. In the univariable analysis, prevalence of S. aureus carriage was higher among children living in villages wholly-vaccinated with PCV-7 [OR = 1.57 95%CI (1.14 to 2.15)] and children with least 1 year of education [OR = 1.44 95%CI (1.07 to 1.92)]. S. aureus carriage was also higher during the rainy season [OR = 1.59 95%CI (1.20 to 2.11)]. Carriage of S. pneumoniae did not have any effect on S. aureus carriage for any pneumococcal, vaccine-type (VT) or non-vaccine-type (NVT) carriage. Multivariate analysis showed that the higher prevalence of S. aureus observed among children living in villages wholly-vaccinated with PCV-7 occurred only during the rainy season OR 2.72 95%CI (1.61-4.60) and not in the dry season OR 1.28 95%CI (0.78-2.09). CONCLUSIONS: Prevalence of nasopharyngeal carriage of S. aureus among Gambian children increased during the rainy season among those children living in PCV-7 wholly vaccinated communities. However, carriage of S. aureus is not associated with carriage of S. pneumoniae. TRIAL REGISTRATION: ISRCTN51695599 . Registered August 04th 2006.
Item Type | Article |
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Faculty and Department |
MRC Gambia > GM-Disease Control and Elimination Theme Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) MRC Gambia > GM-Vaccinology Theme Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
Research Centre | Antimicrobial Resistance Centre (AMR) |
PubMed ID | 28841852 |
ISI | 408448900001 |
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