Idris, Zulkarnain Md; Chan, Chim W; Kongere, James; Hall, Tom; Logedi, John; Gitaka, Jesse; Drakeley, Chris; Kaneko, Akira; (2017) Naturally acquired antibody response to Plasmodium falciparum describes heterogeneity in transmission on islands in Lake Victoria. Scientific reports, 7 (1). 9123-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-017-09585-4
Permanent Identifier
Use this Digital Object Identifier when citing or linking to this resource.
Abstract
As markers of exposure anti-malaria antibody responses can help characterise heterogeneity in malaria transmission. In the present study antibody responses to Plasmodium falciparum AMA-1, MSP-119 and CSP were measured with the aim to describe transmission patterns in meso-endemic settings in Lake Victoria. Two cross-sectional surveys were conducted in Lake Victoria in January and August 2012. The study area comprised of three settings: mainland (Ungoye), large island (Mfangano) and small islands (Takawiri, Kibuogi, Ngodhe). Individuals provided a finger-blood sample to assess malaria infection by microscopy and PCR. Antibody response to P. falciparum was determined in 4,112 individuals by ELISA using eluted dried blood from filter paper. The overall seroprevalence was 64.0% for AMA-1, 39.5% for MSP-119, and 12.9% for CSP. Between settings, seroprevalences for merozoite antigens were similar between Ungoye and Mfangano, but higher when compared to the small islands. For AMA-1, the seroconversion rates (SCRs) ranged from 0.121 (Ngodhe) to 0.202 (Ungoye), and were strongly correlated to parasite prevalence. We observed heterogeneity in serological indices across study sites in Lake Victoria. These data suggest that AMA-1 and MSP-119 sero-epidemiological analysis may provide further evidence in assessing variation in malaria exposure and evaluating malaria control efforts in high endemic area.
Item Type | Article |
---|---|
Faculty and Department |
Faculty of Infectious and Tropical Diseases > Department of Infection Biology > Dept of Immunology and Infection (-2019) Faculty of Infectious and Tropical Diseases > Department of Infection Biology |
Research Centre |
Malaria Centre Vaccine Centre |
PubMed ID | 28831122 |
ISI | 408166400004 |
Related URLs |
Download
Filename: Naturally acquired antibody response to_GOLD VoR.pdf
Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
Download