The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility.

Hanifa, Yasmeen; Telisinghe, Lilanganee; Fielding, Katherine L; Malden, Justin L; Churchyard, Gavin J; Grant, Alison D; Charalambous, Salome; (2015) The diagnostic accuracy of urine lipoarabinomannan test for tuberculosis screening in a South African correctional facility. PloS one, 10 (5). e0127956-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0127956

Abstract

BACKGROUND: We evaluated the diagnostic accuracy of the urine lipoarabinomannan (LAM) antigen detection assay (Clearview TB-ELISA) to screen for tuberculosis in a South African correctional facility. METHODS: Between September 2009 and October 2010, male offenders were screened for tuberculosis (symptoms, chest radiograph, two spot sputum specimens for microscopy and culture), and urine tested for LAM. Sensitivity, specificity and predictive values of LAM were calculated using definite and probable tuberculosis combined as our gold standard. FINDINGS: 33/871 (3.8%) participants (26% HIV-positive) had tuberculosis. Amongst HIV-positive vs. HIV-negative offenders the sensitivity and specificity of LAM was 7.1% vs. 0% and 98.5% vs. 99.8% respectively. CONCLUSION: Urine LAM ELISA has inadequate sensitivity for TB screening in this population.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre	TB Centre Tropical Epidemiology Group
PubMed ID	26010840
ISI	355183900171
Related URLs	OA Location