The evolution of enzyme function in the isomerases.
Martinez Cuesta, Sergio;
Furnham, Nicholas;
Rahman, Syed Asad;
Sillitoe, Ian;
Thornton, Janet M;
(2014)
The evolution of enzyme function in the isomerases.
Current opinion in structural biology, 26 (1).
pp. 121-130.
ISSN 0959-440X
DOI: https://doi.org/10.1016/j.sbi.2014.06.002
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The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure. This paper reviews research efforts aiming to understand the evolution of enzyme function in superfamilies, presenting a novel strategy to provide an overview of the evolution of enzymes belonging to an individual EC class, using the isomerases as an exemplar.
