Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Lindström, Sara;
Vachon, Celine M;
Li, Jingmei;
Varghese, Jajini;
Thompson, Deborah;
Warren, Ruth;
Brown, Judith;
Leyland, Jean;
Audley, Tina;
Wareham, Nicholas J;
+25 more...Loos, Ruth JF;
Paterson, Andrew D;
Rommens, Johanna;
Waggott, Darryl;
Martin, Lisa J;
Scott, Christopher G;
Pankratz, V Shane;
Hankinson, Susan E;
Hazra, Aditi;
Hunter, David J;
Hopper, John L;
Southey, Melissa C;
Chanock, Stephen J;
Silva, Isabel dos Santos;
Liu, JianJun;
Eriksson, Louise;
Couch, Fergus J;
Stone, Jennifer;
Apicella, Carmel;
Czene, Kamila;
Kraft, Peter;
Hall, Per;
Easton, Douglas F;
Boyd, Norman F;
Tamimi, Rulla M;
(2011)
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Nature genetics, 43 (3).
pp. 185-187.
ISSN 1061-4036
DOI: https://doi.org/10.1038/ng.760
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High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
