Vitamin A serostatus and heterosexual transmission of HIV: case-control study in Tanzania and review of the evidence


Villamor, E; Kapiga, SH; Fawzi, WW; (2006) Vitamin A serostatus and heterosexual transmission of HIV: case-control study in Tanzania and review of the evidence. International journal for vitamin and nutrition research Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung Journal international de vitaminologie et de nutrition, 76 (2). pp. 81-5. ISSN 0300-9831 DOI: https://doi.org/10.1024/0300-9831.76.2.81

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Abstract

Results from a randomized clinical trial suggested that vitamin A/beta-carotene supplementation to HIV-1-infected women during pregnancy and lactation may increase the risk of vertical transmission. Limited information is available on the potential role of vitamin A on heterosexual HIV transmission. This is a relevant question in many resource-limited settings where both vitamin A deficiency and HIV infection are highly prevalent. We conducted a case-control study (34 cases and 38 controls) nested within a cohort of HIV-negative women attending family planning clinics in Tanzania, to examine whether low serum concentrations at baseline were associated with the risk of seroconversion. There was not a significant association (OR = 2.14, 95% C I = 0.54, 8.45). In light of these and previous results, we conclude that there is not enough evidence yet to suggest a causal association between vitamin A and heterosexual transmission.

Item Type: Article
Keywords: Case-Control Studies, Cohort Studies, Female, HIV Infections/*blood/*transmission, HIV Seropositivity, HIV-1/*immunology, Humans, Tanzania, Vitamin A/*blood
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 16941419
Web of Science ID: 240245800005
URI: http://researchonline.lshtm.ac.uk/id/eprint/9907

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